University of Connecticut School of Medicine 1 article published in JoVE Biology Recording Gap Junction Current from Xenopus Oocytes Yuan Shui1, Zhao-Wen Wang1 1Department of Neuroscience, University of Connecticut School of Medicine Here we present a protocol to express gap junction proteins in Xenopus oocytes and record junctional current between two apposed oocytes using a commercial amplifier designed for dual oocyte voltage-clamp recordings in a high side current measuring mode.