Harvard Medical School - BIDMC 1 article published in JoVE Immunology and Infection An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics Roberta Martinelli1, Christopher V. Carman1 1Department of Medicine, Harvard Medical School - BIDMC Adaptive immunity is controlled by dynamic 'immunological synapses' formed between T cells and antigen presenting cells. This protocol describes methods for investigating endothelial cells both as understudied physiologic APCs and as a novel type of 'planar cellular APC model'.