Overlook Medical Center 1 article published in JoVE Medicine Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans Diego Iacono1, Maria Geraci-Erck1, Hui Peng1, John Paul Bouffard2 1Neuropathology Research, Biomedical Research Institute of New Jersey (BRInj), 2Department of Pathology, Atlantic Health System (AHS), Overlook Medical Center Organized brain cutting procedures are necessary to correlate specific neuropsychiatric phenomena with definitive neuropathologic diagnoses. Brain cuttings are performed differently based on various clinico-academic contingencies. This protocol describes a symmetric bihemispheric brain cutting procedure to investigate hemispheric differences in human brain pathologies and to maximize current and future biomolecular/neuroimaging techniques.