Aaron P. Mitchell Department of Biological Sciences Carnegie Mellon University Biography Publications Institution JoVE Articles Aaron P. Mitchell has not added a biography. If you are Aaron P. Mitchell and would like to personalize this page please email our Author Liaison for assistance. Publications Roles of Candida Albicans Mig1 and Mig2 in Glucose Repression, Pathogenicity Traits, and SNF1 Essentiality PLoS Genetics. Jan, 2020 | Pubmed ID: 31961865 Genome Sequence for Candida Albicans Clinical Oral Isolate 529L Microbiology Resource Announcements. Jun, 2019 | Pubmed ID: 31221654 MSphere of Influence: the View from the Microbiologists of the Future MSphere. 06, 2019 | Pubmed ID: 31217304 Circuit Diversification in a Biofilm Regulatory Network PLoS Pathogens. 05, 2019 | Pubmed ID: 31116789 Candida Albicans Morphogenesis Programs Control the Balance Between Gut Commensalism and Invasive Infection Cell Host & Microbe. Mar, 2019 | Pubmed ID: 30870623 Function of BriC Peptide in the Pneumococcal Competence and Virulence Portfolio PLoS Pathogens. 10, 2018 | Pubmed ID: 30308062 Functional Convergence of GliP and Aspf1 in Aspergillus Fumigatus Pathogenicity Virulence. 2018 | Pubmed ID: 30052103 Impact of Surface Topography on Biofilm Formation by Candida Albicans PloS One. 2018 | Pubmed ID: 29912894 Rapid Gene Concatenation for Genetic Rescue of Multigene Mutants in MSphere. 04, 2018 | Pubmed ID: 29695626 Conservation and Divergence in the Species Biofilm Matrix Mannan-Glucan Complex Structure, Function, and Genetic Control MBio. 04, 2018 | Pubmed ID: 29615504 A Novel Streptococcal Cell-cell Communication Peptide Promotes Pneumococcal Virulence and Biofilm Formation Molecular Microbiology. Aug, 2017 | Pubmed ID: 28557053 Promiscuous Signaling by a Regulatory System Unique to the Pandemic PMEN1 Pneumococcal Lineage PLoS Pathogens. May, 2017 | Pubmed ID: 28542565 Negative Control of Candida Albicans Filamentation-associated Gene Expression by Essential Protein Kinase Gene KIN28 Current Genetics. Dec, 2017 | Pubmed ID: 28501989 Fungal Biofilms: Inside Out Microbiology Spectrum. 04, 2017 | Pubmed ID: 28387175 Location, Location, Location: Use of CRISPR-Cas9 for Genome Editing in Human Pathogenic Fungi PLoS Pathogens. 03, 2017 | Pubmed ID: 28358867 Marker Recycling in Through CRISPR-Cas9-Induced Marker Excision MSphere. Mar-Apr, 2017 | Pubmed ID: 28317025 Bypass of Candida Albicans Filamentation/Biofilm Regulators Through Diminished Expression of Protein Kinase Cak1 PLoS Genetics. Dec, 2016 | Pubmed ID: 27935965 Candida Albicans Gene Deletion with a Transient CRISPR-Cas9 System MSphere. May-Jun, 2016 | Pubmed ID: 27340698 Sequence-directed Nucleosome-depletion is Sufficient to Activate Transcription from a Yeast Core Promoter In vivo Biochemical and Biophysical Research Communications. 07, 2016 | Pubmed ID: 27208777 Microbiology: Fungus Produces a Toxic Surprise Nature. Apr, 2016 | Pubmed ID: 27027285 Pathogen Gene Expression Profiling During Infection Using a Nanostring NCounter Platform Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26483015 The New Shape of EC Eukaryotic Cell. Dec, 2015 | Pubmed ID: 26622047 Clinical Trial Participants With Metastatic Renal Cell Carcinoma Differ From Patients Treated in Real-World Practice Journal of Oncology Practice / American Society of Clinical Oncology. Nov, 2015 | Pubmed ID: 26330533 Coordination of Candida Albicans Invasion and Infection Functions by Phosphoglycerol Phosphatase Rhr2 Pathogens (Basel, Switzerland). 2015 | Pubmed ID: 26213976 Candida Albicans Biofilm Development and Its Genetic Control Microbiology Spectrum. Jun, 2015 | Pubmed ID: 26185083 A Candida Albicans Strain Expressing Mammalian Interleukin-17A Results in Early Control of Fungal Growth During Disseminated Infection Infection and Immunity. Sep, 2015 | Pubmed ID: 26150537 New Signaling Pathways Govern the Host Response to C. Albicans Infection in Various Niches Genome Research. May, 2015 | Pubmed ID: 25858952 Deferred Systemic Therapy in Patients with Metastatic Renal Cell Carcinoma Clinical Genitourinary Cancer. Jun, 2015 | Pubmed ID: 25770767 Community Participation in Biofilm Matrix Assembly and Function Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015 | Pubmed ID: 25770218 Activation and Alliance of Regulatory Pathways in C. Albicans During Mammalian Infection PLoS Biology. Feb, 2015 | Pubmed ID: 25693184 Divergent Targets of Aspergillus Fumigatus AcuK and AcuM Transcription Factors During Growth in Vitro Versus Invasive Disease Infection and Immunity. Mar, 2015 | Pubmed ID: 25534941 Sudden Motility Reversal Indicates Sensing of Magnetic Field Gradients in Magnetospirillum Magneticum AMB-1 Strain The ISME Journal. Jun, 2015 | Pubmed ID: 25478682 ChIP-seq and in Vivo Transcriptome Analyses of the Aspergillus Fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence PLoS Pathogens. Nov, 2014 | Pubmed ID: 25375670 Fungal Biofilms, Drug Resistance, and Recurrent Infection Cold Spring Harbor Perspectives in Medicine. Oct, 2014 | Pubmed ID: 25274758 Mutational Analysis of Essential Septins Reveals a Role for Septin-mediated Signaling in Filamentation Eukaryotic Cell. Nov, 2014 | Pubmed ID: 25217462 Disruption of the Transcriptional Regulator Cas5 Results in Enhanced Killing of Candida Albicans by Fluconazole Antimicrobial Agents and Chemotherapy. Nov, 2014 | Pubmed ID: 25182640 Novel Entries in a Fungal Biofilm Matrix Encyclopedia MBio. 2014 | Pubmed ID: 25096878 Lack of Timely Accrual Information in Oncology Clinical Trials: a Cross-sectional Analysis Trials. 2014 | Pubmed ID: 24661848 Role of Retrograde Trafficking in Stress Response, Host Cell Interactions, and Virulence of Candida Albicans Eukaryotic Cell. Feb, 2014 | Pubmed ID: 24363364 The Cryptococcus Neoformans Rim101 Transcription Factor Directly Regulates Genes Required for Adaptation to the Host Molecular and Cellular Biology. Feb, 2014 | Pubmed ID: 24324006 Glycerophosphocholine Utilization by Candida Albicans: Role of the Git3 Transporter in Virulence The Journal of Biological Chemistry. Nov, 2013 | Pubmed ID: 24114876 Profiling of Candida Albicans Gene Expression During Intra-abdominal Candidiasis Identifies Biologic Processes Involved in Pathogenesis The Journal of Infectious Diseases. Nov, 2013 | Pubmed ID: 24006479 Aspergillus Galactosaminogalactan Mediates Adherence to Host Constituents and Conceals Hyphal β-glucan from the Immune System PLoS Pathogens. 2013 | Pubmed ID: 23990787 Regulatory Role of Glycerol in Candida Albicans Biofilm Formation MBio. 2013 | Pubmed ID: 23572557 A Competitive Infection Model of Hematogenously Disseminated Candidiasis in Mice Redefines the Role of Candida Albicans IRS4 in Pathogenesis Infection and Immunity. May, 2013 | Pubmed ID: 23429534 Bcr1 Functions Downstream of Ssd1 to Mediate Antimicrobial Peptide Resistance in Candida Albicans Eukaryotic Cell. Mar, 2013 | Pubmed ID: 23314964 A Candida Biofilm-induced Pathway for Matrix Glucan Delivery: Implications for Drug Resistance PLoS Pathogens. 2012 | Pubmed ID: 22876186 Cis- and Trans-acting Localization Determinants of PH Response Regulator Rim13 in Saccharomyces Cerevisiae Eukaryotic Cell. Oct, 2012 | Pubmed ID: 22865500 Statin Cost Effectiveness in Primary Prevention: a Systematic Review of the Recent Cost-effectiveness Literature in the United States BMC Research Notes. 2012 | Pubmed ID: 22828389 Rapid Redistribution of Phosphatidylinositol-(4,5)-bisphosphate and Septins During the Candida Albicans Response to Caspofungin Antimicrobial Agents and Chemotherapy. Sep, 2012 | Pubmed ID: 22687514 Divergent Targets of Candida Albicans Biofilm Regulator Bcr1 in Vitro and in Vivo Eukaryotic Cell. Jul, 2012 | Pubmed ID: 22544909 Fungal Morphogenesis: in Hot Pursuit Current Biology : CB. Apr, 2012 | Pubmed ID: 22497936 Fungal Biofilms PLoS Pathogens. 2012 | Pubmed ID: 22496639 Portrait of Candida Albicans Adherence Regulators PLoS Pathogens. Feb, 2012 | Pubmed ID: 22359502 Mini-blaster-mediated Targeted Gene Disruption and Marker Complementation in Candida Albicans Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22328365 A Case of Highly Aggressive Extraskeletal Myxoid Chondrosarcoma Case Reports in Oncology. May, 2011 | Pubmed ID: 21941486 Zap1 Control of Cell-cell Signaling in Candida Albicans Biofilms Eukaryotic Cell. Nov, 2011 | Pubmed ID: 21890817 Candida Albicans Adds More Weight to Iron Regulation Cell Host & Microbe. Aug, 2011 | Pubmed ID: 21843865 Mucosal Biofilms of Candida Albicans Current Opinion in Microbiology. Aug, 2011 | Pubmed ID: 21741878 Cell Wall Integrity is Linked to Mitochondria and Phospholipid Homeostasis in Candida Albicans Through the Activity of the Post-transcriptional Regulator Ccr4-Pop2 Molecular Microbiology. Feb, 2011 | Pubmed ID: 21299651 Role of Bcr1-activated Genes Hwp1 and Hyr1 in Candida Albicans Oral Mucosal Biofilms and Neutrophil Evasion PloS One. 2011 | Pubmed ID: 21283544 Genetic Control of Candida Albicans Biofilm Development Nature Reviews. Microbiology. Feb, 2011 | Pubmed ID: 21189476 Interaction Between the Candida Albicans High-osmolarity Glycerol (HOG) Pathway and the Response to Human Beta-defensins 2 and 3 Eukaryotic Cell. Feb, 2011 | Pubmed ID: 21131433 Candida Albicans Hyr1p Confers Resistance to Neutrophil Killing and is a Potential Vaccine Target The Journal of Infectious Diseases. Jun, 2010 | Pubmed ID: 20415594 Role of Filamentation in Galleria Mellonella Killing by Candida Albicans Microbes and Infection / Institut Pasteur. Jun, 2010 | Pubmed ID: 20223293 Intervention of Bro1 in PH-responsive Rim20 Localization in Saccharomyces Cerevisiae Eukaryotic Cell. Apr, 2010 | Pubmed ID: 20190076 An Extensive Circuitry for Cell Wall Regulation in Candida Albicans PLoS Pathogens. Feb, 2010 | Pubmed ID: 20140194 In Liver Fibrosis, Dendritic Cells Govern Hepatic Inflammation in Mice Via TNF-alpha The Journal of Clinical Investigation. Nov, 2009 | Pubmed ID: 19855130 Transcriptional Responses of Candida Albicans to Epithelial and Endothelial Cells Eukaryotic Cell. Oct, 2009 | Pubmed ID: 19700637 Biofilm Matrix Regulation by Candida Albicans Zap1 PLoS Biology. Jun, 2009 | Pubmed ID: 19529758 Candida Albicans Cas5, a Regulator of Cell Wall Integrity, is Required for Virulence in Murine and Toll Mutant Fly Models The Journal of Infectious Diseases. Jul, 2009 | Pubmed ID: 19463063 Detection of Protein-protein Interactions Through Vesicle Targeting Genetics. May, 2009 | Pubmed ID: 19307607 Teach, then Trust Elizabeth W. Jones (1939-2008): Mentor to Many Genetics. Feb, 2009 | Pubmed ID: 19233838 Large-scale Gene Disruption Using the UAU1 Cassette Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19152049 Complementary Adhesin Function in C. Albicans Biofilm Formation Current Biology : CB. Jul, 2008 | Pubmed ID: 18635358 Candida Albicans Transcription Factor Rim101 Mediates Pathogenic Interactions Through Cell Wall Functions Cellular Microbiology. Nov, 2008 | Pubmed ID: 18627379 A VAST Staging Area for Regulatory Proteins Proceedings of the National Academy of Sciences of the United States of America. May, 2008 | Pubmed ID: 18474868 Regulation of the Candida Albicans Cell Wall Damage Response by Transcription Factor Sko1 and PAS Kinase Psk1 Molecular Biology of the Cell. Jul, 2008 | Pubmed ID: 18434592 A Nucleosome Positioned by Alpha2/Mcm1 Prevents Hap1 Activator Binding in Vivo Biochemical and Biophysical Research Communications. Dec, 2007 | Pubmed ID: 17959145 Requirement for Candida Albicans Sun41 in Biofilm Formation and Virulence Eukaryotic Cell. Nov, 2007 | Pubmed ID: 17873081 The Fungal Frontier Genome Biology. 2007 | Pubmed ID: 17521458 Microbial Biofilms: E Pluribus Unum Current Biology : CB. May, 2007 | Pubmed ID: 17502083 Candida Albicans Protein Kinase CK2 Governs Virulence During Oropharyngeal Candidiasis Cellular Microbiology. Jan, 2007 | Pubmed ID: 16939537 How to Build a Biofilm: a Fungal Perspective Current Opinion in Microbiology. Dec, 2006 | Pubmed ID: 17055772 Function of Candida Albicans Adhesin Hwp1 in Biofilm Formation Eukaryotic Cell. Oct, 2006 | Pubmed ID: 17030992 Effect of Sequence-directed Nucleosome Disruption on Cell-type-specific Repression by Alpha2/Mcm1 in the Yeast Genome Eukaryotic Cell. Nov, 2006 | Pubmed ID: 16980406 Genetics and Genomics of Candida Albicans Biofilm Formation Cellular Microbiology. Sep, 2006 | Pubmed ID: 16848788 Critical Role of Bcr1-dependent Adhesins in C. Albicans Biofilm Formation in Vitro and in Vivo PLoS Pathogens. Jul, 2006 | Pubmed ID: 16839200 Alcohol Dehydrogenase Restricts the Ability of the Pathogen Candida Albicans to Form a Biofilm on Catheter Surfaces Through an Ethanol-based Mechanism Infection and Immunity. Jul, 2006 | Pubmed ID: 16790752 Cryptococcal Virulence: Beyond the Usual Suspects The Journal of Clinical Investigation. Jun, 2006 | Pubmed ID: 16741574 Control of the C. Albicans Cell Wall Damage Response by Transcriptional Regulator Cas5 PLoS Pathogens. Mar, 2006 | Pubmed ID: 16552442 Control of Bro1-domain Protein Rim20 Localization by External PH, ESCRT Machinery, and the Saccharomyces Cerevisiae Rim101 Pathway Molecular Biology of the Cell. Mar, 2006 | Pubmed ID: 16407402 Effect of Histone Methyltransferase Gene Mutations on Sporulation in S. Cerevisiae Nucleic Acids Symposium Series (2004). 2005 | Pubmed ID: 17150765 Fungal CO2 Sensing: a Breath of Fresh Air Current Biology : CB. Nov, 2005 | Pubmed ID: 16303555 A Human-curated Annotation of the Candida Albicans Genome PLoS Genetics. Jul, 2005 | Pubmed ID: 16103911 Candida Albicans Biofilm-defective Mutants Eukaryotic Cell. Aug, 2005 | Pubmed ID: 16087754 Regulation of Cell-surface Genes and Biofilm Formation by the C. Albicans Transcription Factor Bcr1p Current Biology : CB. Jun, 2005 | Pubmed ID: 15964282 Relationship of DFG16 to the Rim101p PH Response Pathway in Saccharomyces Cerevisiae and Candida Albicans Eukaryotic Cell. May, 2005 | Pubmed ID: 15879523 Yeast Wall Protein 1 of Candida Albicans Microbiology (Reading, England). May, 2005 | Pubmed ID: 15870471 Regulation of Azole Drug Susceptibility by Candida Albicans Protein Kinase CK2 Molecular Microbiology. Apr, 2005 | Pubmed ID: 15813744 Multivesicular Body-ESCRT Components Function in PH Response Regulation in Saccharomyces Cerevisiae and Candida Albicans Molecular Biology of the Cell. Dec, 2004 | Pubmed ID: 15371534 Candida Albicans Rim13p, a Protease Required for Rim101p Processing at Acidic and Alkaline PHs Eukaryotic Cell. Jun, 2004 | Pubmed ID: 15189995 Large-scale Gene Function Analysis in Candida Albicans Trends in Microbiology. Apr, 2004 | Pubmed ID: 15051065 Relationship Between Candida Albicans Virulence During Experimental Hematogenously Disseminated Infection and Endothelial Cell Damage in Vitro Infection and Immunity. Jan, 2004 | Pubmed ID: 14688143 Hap1p Photofootprinting As an in Vivo Assay of Repression Mechanism in Saccharomyces Cerevisiae Methods in Enzymology. 2003 | Pubmed ID: 14712669 Genetic Control of Chlamydospore Formation in Candida Albicans Microbiology (Reading, England). Dec, 2003 | Pubmed ID: 14663094 Updated View of Cryptococcus Neoformans Mating Type and Virulence Infection and Immunity. Sep, 2003 | Pubmed ID: 12933822 Roles of Candida Albicans Dfg5p and Dcw1p Cell Surface Proteins in Growth and Hypha Formation Eukaryotic Cell. Aug, 2003 | Pubmed ID: 12912894 Yeast Ume6p Repressor Permits Activator Binding but Restricts TBP Binding at the HOP1 Promoter Nucleic Acids Research. Jun, 2003 | Pubmed ID: 12799429 Evidence for a Role of Glycogen Synthase Kinase-3 Beta in Rodent Spermatogenesis Journal of Andrology. May-Jun, 2003 | Pubmed ID: 12721208 Spermatogenetic Expression of RNA-binding Motif Protein 7, a Protein That Interacts with Splicing Factors Journal of Andrology. Mar-Apr, 2003 | Pubmed ID: 12634307 The Transcription Factor Rim101p Governs Ion Tolerance and Cell Differentiation by Direct Repression of the Regulatory Genes NRG1 and SMP1 in Saccharomyces Cerevisiae Molecular and Cellular Biology. Jan, 2003 | Pubmed ID: 12509465 Candida Albicans Mds3p, a Conserved Regulator of PH Responses and Virulence Identified Through Insertional Mutagenesis Genetics. Dec, 2002 | Pubmed ID: 12524333 Repression and Activation Domains of RME1p Structurally Overlap, but Differ in Genetic Requirements Molecular Biology of the Cell. May, 2002 | Pubmed ID: 12006664 Mapping of the Proteinase B Structural Gene PRB1, in Saccharomyces Cerevisiae and Identification of Nonsense Alleles Within the Locus Genetics. Sep, 1980 | Pubmed ID: 7009321 Clarifying and Imaging Candida albicans Biofilms Frederick Lanni1, Katherine Lagree1, Manning Y. Huang1, Lan Yan2, Carol A. Woolford1, Aaron P. Mitchell1 1Department of Biological Sciences, Carnegie Mellon University, 2Department of Pharmacology, Second Military Medical University JoVE 60718 Immunology and Infection
Clarifying and Imaging Candida albicans Biofilms Frederick Lanni1, Katherine Lagree1, Manning Y. Huang1, Lan Yan2, Carol A. Woolford1, Aaron P. Mitchell1 1Department of Biological Sciences, Carnegie Mellon University, 2Department of Pharmacology, Second Military Medical University JoVE 60718 Immunology and Infection