Andrew G. Stephen NCI RAS Initiative, Cancer Research Technology Program Frederick National Laboratory for Cancer Research Biography Publications Institution JoVE Articles Andrew G. Stephen has not added a biography. If you are Andrew G. Stephen and would like to personalize this page please email our Author Liaison for assistance. Publications Second Harmonic Generation Detection of Ras Conformational Changes and Discovery of a Small Molecule Binder Proceedings of the National Academy of Sciences of the United States of America. Aug, 2019 | Pubmed ID: 31399543 PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b Biochemistry. Aug, 2019 | Pubmed ID: 31339036 Organization of Farnesylated, Carboxymethylated KRAS4B on Membranes Journal of Molecular Biology. Sep, 2019 | Pubmed ID: 31330153 Structures of N-terminally Processed KRAS Provide Insight into the Role of N-acetylation Scientific Reports. Jul, 2019 | Pubmed ID: 31324887 KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner Biophysical Journal. 03, 2019 | Pubmed ID: 30846362 Quantitative Biophysical Analysis Defines Key Components Modulating Recruitment of the GTPase KRAS to the Plasma Membrane The Journal of Biological Chemistry. 02, 2019 | Pubmed ID: 30559287 New Weapons to Penetrate the Armor: Novel Reagents and Assays Developed at the NCI RAS Initiative to Enable Discovery of RAS Therapeutics Seminars in Cancer Biology. 02, 2019 | Pubmed ID: 29432816 The Bacterial Ras/Rap1 Site-specific Endopeptidase RRSP Cleaves Ras Through an Atypical Mechanism to Disrupt Ras-ERK Signaling Science Signaling. 10, 2018 | Pubmed ID: 30279169 Molecular Recognition of RAS/RAF Complex at the Membrane: Role of RAF Cysteine-rich Domain Scientific Reports. 05, 2018 | Pubmed ID: 29855542 K-Ras4B Remains Monomeric on Membranes over A Wide Range Of Surface Densities and Lipid Compositions Biophysical Journal. 01, 2018 | Pubmed ID: 29320680 Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit Molecular Cell. 12, 2016 | Pubmed ID: 27889448 Structural Basis of Recognition of Farnesylated and Methylated KRAS4b by PDEδ Proceedings of the National Academy of Sciences of the United States of America. 11, 2016 | Pubmed ID: 27791178 Farnesylated and Methylated KRAS4b: High Yield Production of Protein Suitable for Biophysical Studies of Prenylated Protein-lipid Interactions Scientific Reports. Nov, 2015 | Pubmed ID: 26522388 Biochemical Assays for the Discovery of TDP1 Inhibitors Molecular Cancer Therapeutics. Aug, 2014 | Pubmed ID: 25024006 Dragging Ras Back in the Ring Cancer Cell. Mar, 2014 | Pubmed ID: 24651010 Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein Constance Agamasu1, Peter Frank1, Shelley Perkins1, Timothy Waybright1, Simon Messing1, William Gillette1, Andrew G. Stephen1 1NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research JoVE 60703 Biochemistry
Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein Constance Agamasu1, Peter Frank1, Shelley Perkins1, Timothy Waybright1, Simon Messing1, William Gillette1, Andrew G. Stephen1 1NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research JoVE 60703 Biochemistry