Barry Gold Department of Pharmaceutical Sciences University of Pittsburgh Biography Publications Institution JoVE Articles Barry Gold has not added a biography. If you are Barry Gold and would like to personalize this page please email our Author Liaison for assistance. Publications Colon Carcinogenesis in Wild Type and Immune Compromised Mice After Treatment with Azoxymethane, and Azoxymethane with Dextran Sodium Sulfate Molecular Carcinogenesis. Jul, 2015 | Pubmed ID: 26153082 Design and Activity of AP Endonuclease-1 Inhibitors Journal of Chemical Biology. Jul, 2015 | Pubmed ID: 26101550 T-cells Enhance Stem Cell Mutagenesis in the Mouse Colon Mutation Research. Apr, 2015 | Pubmed ID: 25770826 Looking for Waldo: a Potential Thermodynamic Signature to DNA Damage Accounts of Chemical Research. Apr, 2014 | Pubmed ID: 24702131 Comparison of the Biological Effects of MMS and Me-lex, a Minor Groove Methylating Agent: Clarifying the Role of N3-methyladenine Mutation Research. Jan, 2014 | Pubmed ID: 24211855 Site-specific Stabilization of DNA by a Tethered Major Groove Amine, 7-aminomethyl-7-deaza-2'-deoxyguanosine Biochemistry. Oct, 2013 | Pubmed ID: 24131376 Forward: Combating Resistance: Infectious Diseases Future Medicinal Chemistry. Jul, 2013 | Pubmed ID: 23859196 Drug Resistance: the Problem That Keeps on Giving Future Medicinal Chemistry. Jun, 2013 | Pubmed ID: 23734679 Synthesis and Characterization of DNA Minor Groove Binding Alkylating Agents Chemical Research in Toxicology. Jan, 2013 | Pubmed ID: 23234400 Identification and Characterization of Human Apurinic/apyrimidinic Endonuclease-1 Inhibitors Biochemistry. Jul, 2012 | Pubmed ID: 22788932 Small-molecule Inhibitors of DNA Damage-repair Pathways: an Approach to Overcome Tumor Resistance to Alkylating Anticancer Drugs Future Medicinal Chemistry. Jun, 2012 | Pubmed ID: 22709253 Thermodynamic Signature of DNA Damage: Characterization of DNA with a 5-hydroxy-2'-deoxycytidine·2'-deoxyguanosine Base Pair Biochemistry. Mar, 2012 | Pubmed ID: 22332945 Altering the Electrostatic Potential in the Major Groove: Thermodynamic and Structural Characterization of 7-deaza-2'-deoxyadenosine:dT Base Pairing in DNA The Journal of Physical Chemistry. B. Dec, 2011 | Pubmed ID: 22059929 3-Methyl-3-deazaadenine, a Stable Isostere of N3-methyl-adenine, is Efficiently Bypassed by Replication in Vivo and by Transcription in Vitro DNA Repair. Aug, 2011 | Pubmed ID: 21676659 Characterization of DNA with an 8-oxoguanine Modification Nucleic Acids Research. Aug, 2011 | Pubmed ID: 21572101 Methadone-induced Torsade De Pointes The American Journal of Emergency Medicine. May, 2011 | Pubmed ID: 20674223 Effect of N3-methyladenine and an Isosteric Stable Analogue on DNA Polymerization Journal of Nucleic Acids. 2010 | Pubmed ID: 20936169 An Unprecedented Nucleic Acid Capture Mechanism for Excision of DNA Damage Nature. Nov, 2010 | Pubmed ID: 20927102 XRCC1 Deficiency Influences the Cytotoxicity and the Genomic Instability Induced by Me-lex, a Specific Inducer of N3-methyladenine DNA Repair. Jul, 2010 | Pubmed ID: 20471330 Thermodynamic Characterization of DNA with 3-deazaadenine and 3-methyl-3-deazaadenine Substitutions: the Effect of Placing a Hydrophobic Group in the Minor Groove of DNA The Journal of Physical Chemistry. B. Jun, 2010 | Pubmed ID: 20469878 Mutagenicity of N3-methyladenine: a Multi-translesion Polymerase Affair Mutation Research. Jan, 2010 | Pubmed ID: 19874831 High Frequency of Genomic Deletions Induced by Me-lex, a Sequence Selective N3-adenine Methylating Agent, at the Hprt Locus in Chinese Hamster Ovary Cells Mutation Research. Dec, 2009 | Pubmed ID: 19729030 Introduction of Cationic Charge into DNA Near the Major Groove Edge of a Guanine X Cytosine Base Pair: Characterization of Oligodeoxynucleotides Substituted with 7-aminomethyl-7-deaza-2'-deoxyguanosine Journal of the American Chemical Society. Sep, 2009 | Pubmed ID: 19663509 A Facile Synthetic Approach to 7-deazaguanine Nucleosides Via a Boc Protection Strategy Organic Letters. Jun, 2009 | Pubmed ID: 19422208 Enhancing the Engagement of U.S. Private Foundations with Conservation Science Conservation Biology : the Journal of the Society for Conservation Biology. Dec, 2008 | Pubmed ID: 18847442 A Bridging Water Anchors the Tethered 5-(3-aminopropyl)-2'-deoxyuridine Amine in the DNA Major Groove Proximate to the N+2 C.G Base Pair: Implications for Formation of Interstrand 5'-GNC-3' Cross-links by Nitrogen Mustards Biochemistry. Jul, 2008 | Pubmed ID: 18549246 Rev1 and Polzeta Influence Toxicity and Mutagenicity of Me-lex, a Sequence Selective N3-adenine Methylating Agent DNA Repair. Mar, 2008 | Pubmed ID: 18182332 A Study of 7-deaza-2'-deoxyguanosine 2'-deoxycytidine Base Pairing in DNA Nucleic Acids Research. 2007 | Pubmed ID: 17855404 Human Glioma Cell Sensitivity to the Sequence-specific Alkylating Agent Methyl-lexitropsin Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2007 | Pubmed ID: 17255284 The Effect of 3-methyladenine DNA Glycosylase-mediated DNA Repair on the Induction of Toxicity and Diabetes by the Beta-cell Toxicant Streptozotocin Toxicological Sciences : an Official Journal of the Society of Toxicology. Feb, 2007 | Pubmed ID: 17098815 A Review of the Role of the Sequence-dependent Electrostatic Landscape in DNA Alkylation Patterns Chemical Research in Toxicology. Nov, 2006 | Pubmed ID: 17112226 Poly(ADP-ribose) Glycohydrolase Inhibitor As Chemosensitiser of Malignant Melanoma for Temozolomide European Journal of Cancer (Oxford, England : 1990). Dec, 2005 | Pubmed ID: 16288862 Synthesis of C-nucleosides Designed to Participate in Triplex Formation with Native DNA: Specific Recognition of an A:T Base Pair in DNA The Journal of Organic Chemistry. Oct, 2005 | Pubmed ID: 16238307 Incorporation of Cationic Chains in the Dickerson-Drew Dodecamer: Correlation of Energetics, Structure, and Ion and Water Binding Biochemistry. Sep, 2005 | Pubmed ID: 16156670 Molecular Recognition Via Triplex Formation of Mixed Purine/pyrimidine DNA Sequences Using OligoTRIPs Journal of the American Chemical Society. Sep, 2005 | Pubmed ID: 16144414 Structure of B-DNA with Cations Tethered in the Major Groove Biochemistry. May, 2005 | Pubmed ID: 15895989 N3-methyladenine Induces Early Poly(ADP-ribosylation), Reduction of Nuclear Factor-kappa B DNA Binding Ability, and Nuclear Up-regulation of Telomerase Activity Molecular Pharmacology. Feb, 2005 | Pubmed ID: 15548765 Ecology. Ecology for a Crowded Planet Science (New York, N.Y.). May, 2004 | Pubmed ID: 15166349 North American Snake Envenomation: Diagnosis, Treatment, and Management Emergency Medicine Clinics of North America. May, 2004 | Pubmed ID: 15163575 The Werner Syndrome Protein Confers Resistance to the DNA Lesions N3-methyladenine and O6-methylguanine: Implications for WRN Function DNA Repair. Jun, 2004 | Pubmed ID: 15135730 Nucleotide Excision Repair Defect Influences Lethality and Mutagenicity Induced by Me-lex, a Sequence-selective N3-adenine Methylating Agent in the Absence of Base Excision Repair Biochemistry. May, 2004 | Pubmed ID: 15134433 Refractory Thrombocytopenia Despite Treatment for Rattlesnake Envenomation The New England Journal of Medicine. Apr, 2004 | Pubmed ID: 15115843 Triple Helix Forming TRIPside Molecules That Target Mixed Purine/pyrimidine DNA Sequences Biochemistry. Feb, 2004 | Pubmed ID: 14769020 The Biological Effects of N3-methyladenine Journal of Cellular Biochemistry. Feb, 2004 | Pubmed ID: 14743385 DNA Damage and Cytotoxicity Induced by Minor Groove Binding Methyl Sulfonate Esters Biochemistry. Dec, 2003 | Pubmed ID: 14640700 Evidence in Escherichia Coli That N3-methyladenine Lesions and Cytotoxicity Induced by a Minor Groove Binding Methyl Sulfonate Ester Can Be Modulated in Vivo by Netropsin Biochemistry. Nov, 2003 | Pubmed ID: 14580207 Resolution of Compartment Syndrome After Rattlesnake Envenomation Utilizing Non-invasive Measures The Journal of Emergency Medicine. Apr, 2003 | Pubmed ID: 12676299 Design of Triple Helix Forming C-glycoside Molecules Journal of the American Chemical Society. Feb, 2003 | Pubmed ID: 12590536 Inhibition of Telomerase Increases Resistance of Melanoma Cells to Temozolomide, but Not to Temozolomide Combined with Poly (adp-ribose) Polymerase Inhibitor Molecular Pharmacology. Jan, 2003 | Pubmed ID: 12488552 Base Excision Repair and Nucleotide Excision Repair Contribute to the Removal of N-methylpurines from Active Genes DNA Repair. Aug, 2002 | Pubmed ID: 12509290 Effect of Cationic Charge Localization on DNA Structure Biopolymers. Nov, 2002 | Pubmed ID: 12228922 Bites of Venomous Snakes The New England Journal of Medicine. Aug, 2002 | Pubmed ID: 12151473 Thermodynamic and Hydration Effects for the Incorporation of a Cationic 3-aminopropyl Chain into DNA Nucleic Acids Research. Jul, 2002 | Pubmed ID: 12136099 Structure of a Tethered Cationic 3-aminopropyl Chain Incorporated into an Oligodeoxynucleotide: Evidence for 3'-orientation in the Major Groove Accompanied by DNA Bending Journal of the American Chemical Society. Jul, 2002 | Pubmed ID: 12121096 Influences of Base Excision Repair Defects on the Lethality and Mutagenicity Induced by Me-lex, a Sequence-selective N3-adenine Methylating Agent The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12042310 Apoptotic and Genotoxic Effects of a Methyl Sulfonate Ester That Selectively Generates N3-methyladenine and Poly(ADP-ribose) Polymerase Inhibitors in Normal Peripheral Blood Lymphocytes Cancer Chemotherapy and Pharmacology. Mar, 2002 | Pubmed ID: 11935214 Quantification of Colonic Stem Cell Mutations Ryan D. Whetstone1, Barry Gold1 1Department of Pharmaceutical Sciences, University of Pittsburgh JoVE 53240 Developmental Biology
Quantification of Colonic Stem Cell Mutations Ryan D. Whetstone1, Barry Gold1 1Department of Pharmaceutical Sciences, University of Pittsburgh JoVE 53240 Developmental Biology