Chia-Yi Kuan Department of Neuroscience, Center for Brain Immunology and Glia (BIG) University of Virginia School of Medicine Biography Publications Institution JoVE Articles Chia-Yi Kuan has not added a biography. If you are Chia-Yi Kuan and would like to personalize this page please email our Author Liaison for assistance. Publications Brain-targeted Hypoxia-inducible Factor Stabilization Reduces Neonatal Hypoxic-ischemic Brain Injury Neurobiology of Disease. 01, 2021 | Pubmed ID: 33248237 Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 12, 2020 | Pubmed ID: 33127853 Fate Mapping Via CCR2-CreER Mice Reveals Monocyte-to-microglia Transition in Development and Neonatal Stroke Science Advances. Aug, 2020 | Pubmed ID: 32923636 A Murine Photothrombotic Stroke Model with an Increased Fibrin Content and Improved Responses to TPA-lytic Treatment Blood Advances. 04, 2020 | Pubmed ID: 32227212 Early Neutrophil Infiltration is Critical for Inflammation-sensitized Hypoxic-ischemic Brain Injury in Newborns Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 11, 2020 | Pubmed ID: 31842667 Plasma Osteopontin May Predict Neuroinflammation and the Severity of Pediatric Traumatic Brain Injury Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 01, 2020 | Pubmed ID: 30866741 Introduction of Severe Traumatic Brain Injury Care Protocol is Associated with Reduction in Mortality for Pediatric Patients: a Case Study of Children's Healthcare of Atlanta's Neurotrauma Program Journal of Neurosurgery. Pediatrics. 08, 2018 | Pubmed ID: 29799350 Towards Reperfusion-centric Preclinical Stroke Research: Outside the Box of "reperfusion Injury" Neural Regeneration Research. Apr, 2015 | Pubmed ID: 26170803 Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury: Implications for Perioperative Neuroprotection Stroke; a Journal of Cerebral Circulation. Jul, 2015 | Pubmed ID: 26060244 Aryl Hydrocarbon Receptor Mediates Both Proinflammatory and Anti-inflammatory Effects in Lipopolysaccharide-activated Microglia Glia. Jul, 2015 | Pubmed ID: 25690886 Anti-tissue Plasminogen Activator (tPA) As an Effective Therapy of Neonatal Hypoxia-ischemia with and Without Inflammation CNS Neuroscience & Therapeutics. Apr, 2015 | Pubmed ID: 25475942 Neural-specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1 PloS One. 2014 | Pubmed ID: 25531304 Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA Cell. Dec, 2014 | Pubmed ID: 25525875 Protoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease PloS One. 2014 | Pubmed ID: 25506911 Blocking Lymphocyte Trafficking with FTY720 Prevents Inflammation-sensitized Hypoxic-ischemic Brain Injury in Newborns The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2014 | Pubmed ID: 25471584 Synergy of Combined TPA-edaravone Therapy in Experimental Thrombotic Stroke PloS One. 2014 | Pubmed ID: 24911517 Cell Type-specific Dependency on the PI3K/Akt Signaling Pathway for the Endogenous Epo and VEGF Induction by Baicalein in Neurons Versus Astrocytes PloS One. 2013 | Pubmed ID: 23904909 Taming Neonatal Hypoxic-ischemic Brain Injury by Intranasal Delivery of Plasminogen Activator Inhibitor-1 Stroke; a Journal of Cerebral Circulation. Sep, 2013 | Pubmed ID: 23881953 Overexpression of Vascular Endothelial Growth Factor in the Germinal Matrix Induces Neurovascular Proteases and Intraventricular Hemorrhage Science Translational Medicine. Jul, 2013 | Pubmed ID: 23843451 Gsx2 Controls Region-specific Activation of Neural Stem Cells and Injury-induced Neurogenesis in the Adult Subventricular Zone Genes & Development. Jun, 2013 | Pubmed ID: 23723414 Engineering a Lysosomal Enzyme with a Derivative of Receptor-binding Domain of ApoE Enables Delivery Across the Blood-brain Barrier Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013 | Pubmed ID: 23382178 Intranasal Delivery of Cell-penetrating Anti-NF-κB Peptides (Tat-NBD) Alleviates Infection-sensitized Hypoxic-ischemic Brain Injury Experimental Neurology. Sep, 2013 | Pubmed ID: 23353638 Plasminogen Activator Inhibitor-1 Mitigates Brain Injury in a Rat Model of Infection-sensitized Neonatal Hypoxia-ischemia Cerebral Cortex (New York, N.Y. : 1991). May, 2013 | Pubmed ID: 22556277 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy Autophagy. Apr, 2012 | Pubmed ID: 22966490 Mannitol-facilitated Perfusion Staining with 2,3,5-triphenyltetrazolium Chloride (TTC) for Detection of Experimental Cerebral Infarction and Biochemical Analysis Journal of Neuroscience Methods. Jan, 2012 | Pubmed ID: 21982741 Loss of RhoA in Neural Progenitor Cells Causes the Disruption of Adherens Junctions and Hyperproliferation Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21502507 Ex Vivo Diffusion Tensor Imaging and Neuropathological Correlation in a Murine Model of Hypoxia-ischemia-induced Thrombotic Stroke Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Apr, 2011 | Pubmed ID: 21139628 Therapeutic Administration of Plasminogen Activator Inhibitor-1 Prevents Hypoxic-ischemic Brain Injury in Newborns The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2009 | Pubmed ID: 19587273 Developmental and Post-injury Cortical Gliogenesis: a Genetic Fate-mapping Study with Nestin-CreER Mice Glia. Aug, 2009 | Pubmed ID: 19115384 Rac1 Deficiency in the Forebrain Results in Neural Progenitor Reduction and Microcephaly Developmental Biology. Jan, 2009 | Pubmed ID: 19007770 Coordinated Control of Self-renewal and Differentiation of Neural Stem Cells by Myc and the P19ARF-p53 Pathway The Journal of Cell Biology. Dec, 2008 | Pubmed ID: 19114593 JNK2 and JNK3 Combined Are Essential for Apoptosis in Dopamine Neurons of the Substantia Nigra, but Are Not Required for Axon Degeneration Journal of Neurochemistry. Dec, 2008 | Pubmed ID: 19014392 Deleterious Effects of Plasminogen Activators in Neonatal Cerebral Hypoxia-ischemia The American Journal of Pathology. Jun, 2008 | Pubmed ID: 18467699 Promiscuous Recombination of LoxP Alleles During Gametogenesis in Cornea Cre Driver Mice Molecular Vision. 2008 | Pubmed ID: 18385792 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy in Higher Eukaryotes Autophagy. Feb, 2008 | Pubmed ID: 18188003 Requirement of JIP Scaffold Proteins for NMDA-mediated Signal Transduction Genes & Development. Sep, 2007 | Pubmed ID: 17875667 Rac1 Controls the Formation of Midline Commissures and the Competency of Tangential Migration in Ventral Telencephalic Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2007 | Pubmed ID: 17409253 Nestin-CreER Mice Reveal DNA Synthesis by Nonapoptotic Neurons Following Cerebral Ischemia Hypoxia Cerebral Cortex (New York, N.Y. : 1991). Nov, 2007 | Pubmed ID: 17259645 The Roles of Autophagy in Cerebral Ischemia Autophagy. Jan-Feb, 2007 | Pubmed ID: 17035724 Jun NH2-terminal Kinase (JNK) Prevents Nuclear Beta-catenin Accumulation and Regulates Axis Formation in Xenopus Embryos Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17060633 Cdc42 Deficiency Causes Sonic Hedgehog-independent Holoprosencephaly Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17050694 Cerebral Ischemia-hypoxia Induces Intravascular Coagulation and Autophagy The American Journal of Pathology. Aug, 2006 | Pubmed ID: 16877357 Saposin C: Neuronal Effect and CNS Delivery by Liposomes Annals of the New York Academy of Sciences. Aug, 2005 | Pubmed ID: 16179529 Cdc42GAP Regulates C-Jun N-terminal Kinase (JNK)-mediated Apoptosis and Cell Number During Mammalian Perinatal Growth Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16157885 Retinoic Acid Induces CDK Inhibitors and Growth Arrest Specific (Gas) Genes in Neural Crest Cells Development, Growth & Differentiation. Apr, 2005 | Pubmed ID: 15839997 Low Doses of Bromo- and Iododeoxyuridine Produce Near-saturation Labeling of Adult Proliferative Populations in the Dentate Gyrus The European Journal of Neuroscience. Feb, 2005 | Pubmed ID: 15733099 Targeting the JNK Signaling Pathway for Stroke and Parkinson's Diseases Therapy Current Drug Targets. CNS and Neurological Disorders. Feb, 2005 | Pubmed ID: 15723614 Mixed Lineage Kinase-c-jun N-terminal Kinase Signaling Pathway: a New Therapeutic Target in Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Jun, 2005 | Pubmed ID: 15719422 Specific Pathophysiological Functions of JNK Isoforms in the Brain The European Journal of Neuroscience. Jan, 2005 | Pubmed ID: 15673436 Hypoxia-ischemia Induces DNA Synthesis Without Cell Proliferation in Dying Neurons in Adult Rodent Brain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2004 | Pubmed ID: 15564594 Modulation of Germ Cell Apoptosis with a Nitric Oxide Synthase Inhibitor in a Murine Model of Congenital Cryptorchidism The Journal of Urology. Oct, 2004 | Pubmed ID: 15371801 A Critical Role of Neural-specific JNK3 for Ischemic Apoptosis Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14657393 C-Jun N-terminal Kinases (JNK) Antagonize Cardiac Growth Through Cross-talk with Calcineurin-NFAT Signaling The EMBO Journal. Oct, 2003 | Pubmed ID: 14517246 Midgestational Lethality in Mice Lacking the Parathyroid Hormone (PTH)/PTH-related Peptide Receptor is Associated with Abrupt Cardiomyocyte Death Endocrinology. Mar, 2003 | Pubmed ID: 12586782 A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model Yi-Min Kuo1, Yu-Yo Sun2, Chia-Yi Kuan2 1Department of Anesthesiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, 2Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine JoVE 61740 Neuroscience A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia Yu-Yo Sun1, Chia-Yi Kuan1 1Department of Pediatrics, Division of Neurology, The Emory University School of Medicine JoVE 52978 Medicine
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model Yi-Min Kuo1, Yu-Yo Sun2, Chia-Yi Kuan2 1Department of Anesthesiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, 2Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine JoVE 61740 Neuroscience
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia Yu-Yo Sun1, Chia-Yi Kuan1 1Department of Pediatrics, Division of Neurology, The Emory University School of Medicine JoVE 52978 Medicine