Christopher D. Link Institute for Behavioral Genetics University of Colorado Biography Publications Institution JoVE Articles Christopher D. Link has not added a biography. If you are Christopher D. Link and would like to personalize this page please email our Author Liaison for assistance. Publications A Glycine Zipper Motif Mediates the Formation of Toxic β-amyloid Oligomers in Vitro and in Vivo Molecular Neurodegeneration. 2011 | Pubmed ID: 21861874 Genetic Dissection of Late-life Fertility in Caenorhabditis Elegans The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Aug, 2011 | Pubmed ID: 21622982 Insulin-like Signaling Determines Survival During Stress Via Posttranscriptional Mechanisms in C. Elegans Cell Metabolism. Sep, 2010 | Pubmed ID: 20816092 Genetic Mechanisms of Coffee Extract Protection in a Caenorhabditis Elegans Model of β-amyloid Peptide Toxicity Genetics. Nov, 2010 | Pubmed ID: 20805557 Neurotoxic Effects of TDP-43 Overexpression in C. Elegans Human Molecular Genetics. Aug, 2010 | Pubmed ID: 20530643 Behavioral Phenotyping of a Transgenic Caenorhabditis Elegans Expressing Neuronal Amyloid-beta Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20110612 Life-span Extension by Dietary Restriction is Mediated by NLP-7 Signaling and Coelomocyte Endocytosis in C. Elegans FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2010 | Pubmed ID: 19783783 Behavioral Phenotyping of a Transgenic C. Elegans Expressing Neuronal Amyloid-beta Journal of Alzheimer's Disease : JAD. Nov, 2009 | Pubmed ID: 19893168 What Have Worm Models Told Us About the Mechanisms of Neuronal Dysfunction in Human Neurodegenerative Diseases? Molecular Neurodegeneration. 2009 | Pubmed ID: 19785750 AIP-1 Ameliorates Beta-amyloid Peptide Toxicity in a Caenorhabditis Elegans Alzheimer's Disease Model Human Molecular Genetics. Aug, 2009 | Pubmed ID: 19414486 Aberrant Cleavage of TDP-43 Enhances Aggregation and Cellular Toxicity Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19383787 The Beta Amyloid Peptide Can Act As a Modular Aggregation Domain Neurobiology of Disease. Dec, 2008 | Pubmed ID: 18778773 Suppression of in Vivo Beta-amyloid Peptide Toxicity by Overexpression of the HSP-16.2 Small Chaperone Protein The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17993648 Decreased Insulin-receptor Signaling Promotes the Autophagic Degradation of Beta-amyloid Peptide in C. Elegans Autophagy. Nov-Dec, 2007 | Pubmed ID: 17675890 Amyloid-beta-induced Pathological Behaviors Are Suppressed by Ginkgo Biloba Extract EGb 761 and Ginkgolides in Transgenic Caenorhabditis Elegans The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2006 | Pubmed ID: 17167099 C. Elegans Models of Age-associated Neurodegenerative Diseases: Lessons from Transgenic Worm Models of Alzheimer's Disease Experimental Gerontology. Oct, 2006 | Pubmed ID: 16930903 Conversion of Green Fluorescent Protein into a Toxic, Aggregation-prone Protein by C-terminal Addition of a Short Peptide The Journal of Biological Chemistry. Jan, 2006 | Pubmed ID: 16239215 Proteomic Identification of Proteins Specifically Oxidized in Caenorhabditis Elegans Expressing Human Abeta(1-42): Implications for Alzheimer's Disease Neurobiology of Aging. Sep, 2006 | Pubmed ID: 16099075 Soy Isoflavone Glycitein Protects Against Beta Amyloid-induced Toxicity and Oxidative Stress in Transgenic Caenorhabditis Elegans BMC Neuroscience. 2005 | Pubmed ID: 16122394 A Pilot Proteomic Study of Amyloid Precursor Interactors in Alzheimer's Disease Annals of Neurology. Aug, 2005 | Pubmed ID: 16049941 Compensatory Regulation Among ER Chaperones in C. Elegans FEBS Letters. Jun, 2005 | Pubmed ID: 15907843 Expression of the Small Heat-shock Protein Hsp16-2 in Caenorhabditis Elegans is Suppressed by Ginkgo Biloba Extract EGb 761 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2003 | Pubmed ID: 14525938 A Stress-responsive Glutathione S-transferase Confers Resistance to Oxidative Stress in Caenorhabditis Elegans Free Radical Biology & Medicine. Jun, 2003 | Pubmed ID: 12757851 Oxidative Stress Precedes Fibrillar Deposition of Alzheimer's Disease Amyloid Beta-peptide (1-42) in a Transgenic Caenorhabditis Elegans Model Neurobiology of Aging. May-Jun, 2003 | Pubmed ID: 12600717 Gene Expression Analysis in a Transgenic Caenorhabditis Elegans Alzheimer's Disease Model Neurobiology of Aging. May-Jun, 2003 | Pubmed ID: 12600716 Functional Analysis of the Glutathione S-transferase 3 from Onchocerca Volvulus (Ov-GST-3): a Parasite GST Confers Increased Resistance to Oxidative Stress in Caenorhabditis Elegans Journal of Molecular Biology. Jan, 2003 | Pubmed ID: 12473450 Interaction of Intracellular Beta Amyloid Peptide with Chaperone Proteins Proceedings of the National Academy of Sciences of the United States of America. Jul, 2002 | Pubmed ID: 12089340 Reporter Transgenes for Study of Oxidant Stress in Caenorhabditis Elegans Methods in Enzymology. 2002 | Pubmed ID: 12078522 A Global Analysis of Caenorhabditis Elegans Operons Nature. Jun, 2002 | Pubmed ID: 12075352 Identification of a Novel Cis-regulatory Element Involved in the Heat Shock Response in Caenorhabditis Elegans Using Microarray Gene Expression and Computational Methods Genome Research. May, 2002 | Pubmed ID: 11997337 Assaying β-amyloid Toxicity using a Transgenic C. elegans Model Vishantie Dostal1, Christopher D. Link1,2 1Institute for Behavioral Genetics, University of Colorado, 2Integrative Physiology, University of Colorado JoVE 2252 Neuroscience
Assaying β-amyloid Toxicity using a Transgenic C. elegans Model Vishantie Dostal1, Christopher D. Link1,2 1Institute for Behavioral Genetics, University of Colorado, 2Integrative Physiology, University of Colorado JoVE 2252 Neuroscience