Haichao Wang The Feinstein Institute for Medical Research North Shore – LIJ Health System Biography Publications Institution JoVE Articles Haichao Wang has not added a biography. If you are Haichao Wang and would like to personalize this page please email our Author Liaison for assistance. Publications Exposure of Perfluorononanoic Acid Suppresses the Hepatic Insulin Signal Pathway and Increases Serum Glucose in Rats Toxicology. Apr, 2012 | Pubmed ID: 22387981 Inhibition of HMGB1 Enhances Bacterial Clearance and Protects Against P. Aeruginosa Pneumonia in Cystic Fibrosis Molecular Medicine (Cambridge, Mass.). Feb, 2012 | Pubmed ID: 22314397 Anti-Inflammatory Role of Fetuin-A in Injury and Infection Current Molecular Medicine. Jan, 2012 | Pubmed ID: 22292896 Recombinant Human MFG-E8 Attenuates Cerebral Ischemic Injury: Its Role in Anti-inflammation and Anti-apoptosis Neuropharmacology. Feb, 2012 | Pubmed ID: 21964436 Peripheral Administration of Human Adrenomedullin and Its Binding Protein Attenuates Stroke-induced Apoptosis and Brain Injury in Rats Molecular Medicine (Cambridge, Mass.). Sep-Oct, 2011 | Pubmed ID: 21695352 HMGB1 Cytoplasmic Translocation in Patients with Acute Liver Failure BMC Gastroenterology. 2011 | Pubmed ID: 21406085 EGCG Stimulates Autophagy and Reduces Cytoplasmic HMGB1 Levels in Endotoxin-stimulated Macrophages Biochemical Pharmacology. May, 2011 | Pubmed ID: 21371444 A Hepatic Protein, Fetuin-A, Occupies a Protective Role in Lethal Systemic Inflammation PloS One. 2011 | Pubmed ID: 21347455 A Critical Cysteine is Required for HMGB1 Binding to Toll-like Receptor 4 and Activation of Macrophage Cytokine Release Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20547845 [Effect of HMGB1 on Human Hepatoma Cell Line-HepG2 Proliferation] Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences. May, 2010 | Pubmed ID: 20543468 Peripheral Administration of Fetuin-A Attenuates Early Cerebral Ischemic Injury in Rats Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2010 | Pubmed ID: 19953099 High Mobility Group Box 1 Protein As a Potential Drug Target for Infection- and Injury-elicited Inflammation Inflammation & Allergy Drug Targets. Mar, 2010 | Pubmed ID: 19906009 Immature Dendritic Cell-derived Exosomes Rescue Septic Animals Via Milk Fat Globule Epidermal Growth Factor-factor VIII [corrected] Journal of Immunology (Baltimore, Md. : 1950). Nov, 2009 | Pubmed ID: 19812188 High-mobility Group Box 1 Protein Induces Tissue Factor Expression in Vascular Endothelial Cells Via Activation of NF-kappaB and Egr-1 Thrombosis and Haemostasis. Aug, 2009 | Pubmed ID: 19652887 Spermine Protects Mice Against Lethal Sepsis Partly by Attenuating Surrogate Inflammatory Markers Molecular Medicine (Cambridge, Mass.). Jul-Aug, 2009 | Pubmed ID: 19593412 Orexigenic Hormone Ghrelin Ameliorates Gut Barrier Dysfunction in Sepsis in Rats Critical Care Medicine. Aug, 2009 | Pubmed ID: 19531942 Novel HMGB1-inhibiting Therapeutic Agents for Experimental Sepsis Shock (Augusta, Ga.). Oct, 2009 | Pubmed ID: 19333143 Quercetin Prevents LPS-induced High-mobility Group Box 1 Release and Proinflammatory Function American Journal of Respiratory Cell and Molecular Biology. Dec, 2009 | Pubmed ID: 19265175 Ethyl Pyruvate Improves Survival in Awake Hemorrhage Journal of Molecular Medicine (Berlin, Germany). Apr, 2009 | Pubmed ID: 19172241 Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1 International Journal of Clinical and Experimental Medicine. 2008 | Pubmed ID: 19079688 Therapeutic Potential of HMGB1-targeting Agents in Sepsis Expert Reviews in Molecular Medicine. 2008 | Pubmed ID: 18980707 Splenectomy Protects Against Sepsis Lethality and Reduces Serum HMGB1 Levels Journal of Immunology (Baltimore, Md. : 1950). Sep, 2008 | Pubmed ID: 18714026 PACAP Inhibit the Release and Cytokine Activity of HMGB1 and Improve the Survival During Lethal Endotoxemia International Immunopharmacology. Dec, 2008 | Pubmed ID: 18713653 Hyperglycemia Aggravates Endotoxin-induced High Mobility Group Box 1 Protein Release: Yet Another Reason Not to Be Too Sweet Critical Care Medicine. Aug, 2008 | Pubmed ID: 18664811 [The Expression of Fetuin-A and Its Pathological Significance in Fulminant Hepatic Failure in Mice] Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology. Jun, 2008 | Pubmed ID: 18578995 A Pilot Study to Detect High Mobility Group Box 1 and Heat Shock Protein 72 in Cerebrospinal Fluid of Pediatric Patients with Meningitis Critical Care Medicine. Jan, 2008 | Pubmed ID: 18090368 Alveolar Macrophage Suppression in Sepsis is Associated with High Mobility Group Box 1 Transmigration Shock (Augusta, Ga.). Jun, 2008 | Pubmed ID: 18004227 [Serum Level of HMGB1 in Patients with Hepatitis B and Its Clinical Significance] Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology. Nov, 2007 | Pubmed ID: 18073062 A Major Ingredient of Green Tea Rescues Mice from Lethal Sepsis Partly by Inhibiting HMGB1 PloS One. 2007 | Pubmed ID: 17987129 Transcutaneous Vagus Nerve Stimulation Reduces Serum High Mobility Group Box 1 Levels and Improves Survival in Murine Sepsis Critical Care Medicine. Dec, 2007 | Pubmed ID: 17901837 Adrenomedullin and Adrenomedullin Binding Protein-1 Prevent Acute Lung Injury After Gut Ischemia-reperfusion Journal of the American College of Surgeons. Aug, 2007 | Pubmed ID: 17660075 The Anti-inflammatory Effects of Heat Shock Protein 72 Involve Inhibition of High-mobility-group Box 1 Release and Proinflammatory Function in Macrophages Journal of Immunology (Baltimore, Md. : 1950). Jul, 2007 | Pubmed ID: 17617616 A Novel Role for HMGB1 in TLR9-mediated Inflammatory Responses to CpG-DNA Blood. Sep, 2007 | Pubmed ID: 17548579 Nuclear Heat Shock Protein 72 As a Negative Regulator of Oxidative Stress (hydrogen Peroxide)-induced HMGB1 Cytoplasmic Translocation and Release Journal of Immunology (Baltimore, Md. : 1950). Jun, 2007 | Pubmed ID: 17513788 HMGB1 As a Potential Therapeutic Target Novartis Foundation Symposium. 2007 | Pubmed ID: 17380789 A Cardiovascular Drug Rescues Mice from Lethal Sepsis by Selectively Attenuating a Late-acting Proinflammatory Mediator, High Mobility Group Box 1 Journal of Immunology (Baltimore, Md. : 1950). Mar, 2007 | Pubmed ID: 17339485 Hydrogen Peroxide Stimulates Macrophages and Monocytes to Actively Release HMGB1 Journal of Leukocyte Biology. Mar, 2007 | Pubmed ID: 17135572 HMGB1 Signals Through Toll-like Receptor (TLR) 4 and TLR2 Shock (Augusta, Ga.). Aug, 2006 | Pubmed ID: 16878026 Role of HMGB1 in Apoptosis-mediated Sepsis Lethality The Journal of Experimental Medicine. Jul, 2006 | Pubmed ID: 16818669 Elevated High-mobility Group Box 1 Levels in Patients with Cerebral and Myocardial Ischemia Shock (Augusta, Ga.). Jun, 2006 | Pubmed ID: 16721263 Potential Role of High Mobility Group Box 1 in Viral Infectious Diseases Viral Immunology. 2006 | Pubmed ID: 16553546 Role of HMGB1 in Cardiovascular Diseases Current Opinion in Pharmacology. Apr, 2006 | Pubmed ID: 16487750 The Aqueous Extract of a Popular Herbal Nutrient Supplement, Angelica Sinensis, Protects Mice Against Lethal Endotoxemia and Sepsis The Journal of Nutrition. Feb, 2006 | Pubmed ID: 16424112 More Tea for Septic Patients?--Green Tea May Reduce Endotoxin-induced Release of High Mobility Group Box 1 and Other Pro-inflammatory Cytokines Medical Hypotheses. 2006 | Pubmed ID: 16266789 Interferon-gamma Inhibition Attenuates Lethality After Cecal Ligation and Puncture in Rats: Implication of High Mobility Group Box-1 Shock (Augusta, Ga.). Oct, 2005 | Pubmed ID: 16205327 Suppressor Alphabeta T Lymphocytes Control Innate Resistance to Endotoxic Shock The Journal of Infectious Diseases. Sep, 2005 | Pubmed ID: 16107957 The Cytokine Activity of HMGB1 Journal of Leukocyte Biology. Jul, 2005 | Pubmed ID: 15734795 Adrenomedullin and Its Binding Protein Attenuate the Proinflammatory Response After Hemorrhage Critical Care Medicine. Feb, 2005 | Pubmed ID: 15699844 Suppression of HMGB1 Release by Stearoyl Lysophosphatidylcholine:an Additional Mechanism for Its Therapeutic Effects in Experimental Sepsis Journal of Lipid Research. Apr, 2005 | Pubmed ID: 15687351 Cholinergic Agonists Inhibit HMGB1 Release and Improve Survival in Experimental Sepsis Nature Medicine. Nov, 2004 | Pubmed ID: 15502843 Bacterial Endotoxin Stimulates Macrophages to Release HMGB1 Partly Through CD14- and TNF-dependent Mechanisms Journal of Leukocyte Biology. Nov, 2004 | Pubmed ID: 15331624 Pathogenic Role of HMGB1 in SARS? Medical Hypotheses. 2004 | Pubmed ID: 15325019 Bench to Bedside: HMGB1-a Novel Proinflammatory Cytokine and Potential Therapeutic Target for Septic Patients in the Emergency Department Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine. Aug, 2004 | Pubmed ID: 15289194 Recombinant HMGB1 with Cytokine-stimulating Activity Journal of Immunological Methods. Jun, 2004 | Pubmed ID: 15251426 Extracellular HMGB1 As a Proinflammatory Cytokine Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Jun, 2004 | Pubmed ID: 15212706 Lipid Unites Disparate Syndromes of Sepsis Nature Medicine. Feb, 2004 | Pubmed ID: 14760415 Reversing Established Sepsis with Antagonists of Endogenous High-mobility Group Box 1 Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14695889 Further Characterization of High Mobility Group Box 1 (HMGB1) As a Proinflammatory Cytokine: Central Nervous System Effects Cytokine. Dec, 2003 | Pubmed ID: 14609567 Structural Basis for the Proinflammatory Cytokine Activity of High Mobility Group Box 1 Molecular Medicine (Cambridge, Mass.). Jan-Feb, 2003 | Pubmed ID: 12765338 IFN-gamma Induces High Mobility Group Box 1 Protein Release Partly Through a TNF-dependent Mechanism Journal of Immunology (Baltimore, Md. : 1950). Apr, 2003 | Pubmed ID: 12646658 Activation of Gene Expression in Human Neutrophils by High Mobility Group Box 1 Protein American Journal of Physiology. Cell Physiology. Apr, 2003 | Pubmed ID: 12620891 Nicotinic Acetylcholine Receptor Alpha7 Subunit is an Essential Regulator of Inflammation Nature. Jan, 2003 | Pubmed ID: 12508119 HMGB1 As a Cytokine and Therapeutic Target Journal of Endotoxin Research. 2002 | Pubmed ID: 12697092 HMGB-1, a DNA-binding Protein with Cytokine Activity, Induces Brain TNF and IL-6 Production, and Mediates Anorexia and Taste Aversion Cytokine. May, 2002 | Pubmed ID: 12126646 Globin Attenuates the Innate Immune Response to Endotoxin Shock (Augusta, Ga.). Jun, 2002 | Pubmed ID: 12069185 Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies Wei Li1, Shu Zhu1, Yusong Zhang1, Jianhua Li1, Andrew E. Sama1, Ping Wang1, Haichao Wang1 1The Feinstein Institute for Medical Research, North Shore – LIJ Health System JoVE 3926 Medicine
Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies Wei Li1, Shu Zhu1, Yusong Zhang1, Jianhua Li1, Andrew E. Sama1, Ping Wang1, Haichao Wang1 1The Feinstein Institute for Medical Research, North Shore – LIJ Health System JoVE 3926 Medicine