Hang Lin Department of Orthopaedic Surgery University of Pittsburgh School of Medicine Biography Publications Institution JoVE Articles Hang Lin has not added a biography. If you are Hang Lin and would like to personalize this page please email our Author Liaison for assistance. Publications In Vitro Study to Identify Ligand-independent Function of Estrogen Receptor-α in Suppressing DNA Damage-induced Chondrocyte Senescence FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2023 | Pubmed ID: 36622202 PEG Reinforced Scaffold Promotes Uniform Distribution of Human MSC-Created Cartilage Matrix Gels (Basel, Switzerland). Dec, 2022 | Pubmed ID: 36547318 Differences in the Intrinsic Chondrogenic Potential of Human Mesenchymal Stromal Cells and IPSC-derived Multipotent Cells Clinical and Translational Medicine. Dec, 2022 | Pubmed ID: 36536500 Experimental Models to Study Osteoarthritis Pain and Develop Therapeutics Osteoarthritis and Cartilage Open. Dec, 2022 | Pubmed ID: 36474784 Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes Biology. Jun, 2022 | Pubmed ID: 36101377 Synovial Joint-on-a-chip for Modeling Arthritis: Progress, Pitfalls, and Potential Trends in Biotechnology. Aug, 2022 | Pubmed ID: 35995600 Aberrant Expression of and in Infrapatellar Fat Pad-Derived ASCs from Pre-Diabetic Donors Cells. Aug, 2022 | Pubmed ID: 35954211 Modeling Early Changes Associated with Cartilage Trauma Using Human-cell-laden Hydrogel Cartilage Models Stem Cell Research & Therapy. Aug, 2022 | Pubmed ID: 35927702 Generation of Hyaline-like Cartilage Tissue from Human Mesenchymal Stromal Cells Within the Self-generated Extracellular Matrix Acta Biomaterialia. Sep, 2022 | Pubmed ID: 35779770 Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Jul, 2022 | Pubmed ID: 35436042 Engineering Pre-vascularized Bone-like Tissue from Human Mesenchymal Stem Cells Through Simulating Endochondral Ossification Biomaterials. Apr, 2022 | Pubmed ID: 35259584 Role of Canonical Wnt/β-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 35141220 Novel Role of Estrogen Receptor-α on Regulating Chondrocyte Phenotype and Response to Mechanical Loading Osteoarthritis and Cartilage. Feb, 2022 | Pubmed ID: 34767957 Engineering Osteoarthritic Cartilage Model Through Differentiating Senescent Human Mesenchymal Stem Cells for Testing Disease-modifying Drugs Science China. Life Sciences. Feb, 2022 | Pubmed ID: 34109475 Macrophages Modulate the Function of MSC- and IPSC-Derived Fibroblasts in the Presence of Polyethylene Particles International Journal of Molecular Sciences. Nov, 2021 | Pubmed ID: 34884641 Graphene Oxide-functionalized Nanocomposites Promote Osteogenesis of Human Mesenchymal Stem Cells Via Enhancement of BMP-SMAD1/5 Signaling Pathway Biomaterials. Oct, 2021 | Pubmed ID: 34464823 Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries Frontiers in Pharmacology. 2021 | Pubmed ID: 34220525 Caveolin-1 Mediates Soft Scaffold-enhanced Adipogenesis of Human Mesenchymal Stem Cells Stem Cell Research & Therapy. Jun, 2021 | Pubmed ID: 34127047 Dynamic Loading Enhances Chondrogenesis of Human Chondrocytes Within a Biodegradable Resilient Hydrogel Biomaterials Science. Jul, 2021 | Pubmed ID: 34109952 The Effects of Macrophage Phenotype on Osteogenic Differentiation of MSCs in the Presence of Polyethylene Particles Biomedicines. May, 2021 | Pubmed ID: 34062822 Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From Expanded Human Chondrocytes Frontiers in Bioengineering and Biotechnology. 2021 | Pubmed ID: 33996787 Enhancing the Potential of Aged Human Articular Chondrocytes for High-quality Cartilage Regeneration FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2021 | Pubmed ID: 33617078 Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling Handbook of Experimental Pharmacology. 2021 | Pubmed ID: 33471201 Current Models for Development of Disease-Modifying Osteoarthritis Drugs Tissue Engineering. Part C, Methods. Feb, 2021 | Pubmed ID: 33403944 Dead Muscle Tissue Promotes Dystrophic Calcification by Lowering Circulating TGF-β1 Level Bone & Joint Research. Nov, 2020 | Pubmed ID: 33135464 Role of Mitochondria in Mediating Chondrocyte Response to Mechanical Stimuli Life Sciences. Dec, 2020 | Pubmed ID: 33086121 Mesenchymal Stem Cell-derived Extracellular Matrix (mECM): a Bioactive and Versatile Scaffold for Musculoskeletal Tissue Engineering Biomedical Materials (Bristol, England). Dec, 2020 | Pubmed ID: 32906098 Injectable BMP-2 Gene-activated Scaffold for the Repair of Cranial Bone Defect in Mice Stem Cells Translational Medicine. Dec, 2020 | Pubmed ID: 32785966 Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models Biology. Jul, 2020 | Pubmed ID: 32751156 Adipose Tissue-Derived Stem Cells Retain Their Adipocyte Differentiation Potential in Three-Dimensional Hydrogels and Bioreactors Biomolecules. Jul, 2020 | Pubmed ID: 32709032 Macrophage Effects on Mesenchymal Stem Cell Osteogenesis in a Three-Dimensional Bone Model Tissue Engineering. Part A. Oct, 2020 | Pubmed ID: 32312178 TGF-β1 Plays a Protective Role in Glucocorticoid-induced Dystrophic Calcification Bone. Jul, 2020 | Pubmed ID: 32259685 Exploration of Metformin As Novel Therapy for Osteoarthritis: Preventing Cartilage Degeneration and Reducing Pain Behavior Arthritis Research & Therapy. Feb, 2020 | Pubmed ID: 32087740 Acceleration of Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Sustained Growth Factor Release in 3D Graphene Oxide Incorporated Hydrogels Acta Biomaterialia. Mar, 2020 | Pubmed ID: 32035282 Incorporating Silica-coated Graphene in Bioceramic Nanocomposites to Simultaneously Enhance Mechanical and Biological Performance Journal of Biomedical Materials Research. Part A. Apr, 2020 | Pubmed ID: 31925910 Condensation-Driven Chondrogenesis of Human Mesenchymal Stem Cells Within Their Own Extracellular Matrix: Formation of Cartilage with Low Hypertrophy and Physiologically Relevant Mechanical Properties Advanced Biosystems. Dec, 2019 | Pubmed ID: 32648682 Osteochondral Tissue Chip Derived From IPSCs: Modeling OA Pathologies and Testing Drugs Frontiers in Bioengineering and Biotechnology. 2019 | Pubmed ID: 31921815 Infiltration and In-Tissue Polymerization of Photocross-Linked Hydrogel for Effective Fixation of Implants into Cartilage-An In Vitro Study ACS Omega. Nov, 2019 | Pubmed ID: 31737812 A Cellularized Biphasic Implant Based on a Bioactive Silk Fibroin Promotes Integration and Tissue Organization During Osteochondral Defect Repair in a Porcine Model International Journal of Molecular Sciences. Oct, 2019 | Pubmed ID: 31627374 Muscle Injury Promotes Heterotopic Ossification by Stimulating Local Bone Morphogenetic Protein-7 Production Journal of Orthopaedic Translation. Jul, 2019 | Pubmed ID: 31508317 Efficient in Vivo Bone Formation by BMP-2 Engineered Human Mesenchymal Stem Cells Encapsulated in a Projection Stereolithographically Fabricated Hydrogel Scaffold Stem Cell Research & Therapy. Aug, 2019 | Pubmed ID: 31412905 Robust Bone Regeneration Through Endochondral Ossification of Human Mesenchymal Stem Cells Within Their Own Extracellular Matrix Biomaterials. Oct, 2019 | Pubmed ID: 31310952 The Efficacy and Safety of Tranexamic Acid for Reducing Blood Loss Following Simultaneous Bilateral Total Knee Arthroplasty: a Multicenter Retrospective Study BMC Musculoskeletal Disorders. Jul, 2019 | Pubmed ID: 31299945 A Bioactive Cartilage Graft of IGF1-Transduced Adipose Mesenchymal Stem Cells Embedded in an Alginate/Bovine Cartilage Matrix Tridimensional Scaffold Stem Cells International. 2019 | Pubmed ID: 31149016 Transplantation of Adult Spinal Cord Tissue: Transection Spinal Cord Repair and Potential Clinical Translation Science China. Life Sciences. Jun, 2019 | Pubmed ID: 31124004 Optimization of Photocrosslinked Gelatin/hyaluronic Acid Hybrid Scaffold for the Repair of Cartilage Defect Journal of Tissue Engineering and Regenerative Medicine. Aug, 2019 | Pubmed ID: 31066519 Engineering Hyaline Cartilage from Mesenchymal Stem Cells with Low Hypertrophy Potential Via Modulation of Culture Conditions and Wnt/β-catenin Pathway Biomaterials. Feb, 2019 | Pubmed ID: 30544046 Enhancing Chondrogenesis and Mechanical Strength Retention in Physiologically Relevant Hydrogels with Incorporation of Hyaluronic Acid and Direct Loading of TGF-β Acta Biomaterialia. Jan, 2019 | Pubmed ID: 30458242 Bone Marrow Mesenchymal Stem Cells: Aging and Tissue Engineering Applications to Enhance Bone Healing Biomaterials. May, 2019 | Pubmed ID: 29980291 Chondroinductive Factor-free Chondrogenic Differentiation of Human Mesenchymal Stem Cells in Graphene Oxide-incorporated Hydrogels Journal of Materials Chemistry. B. Feb, 2018 | Pubmed ID: 32254371 Influence of Cholesterol/caveolin-1/caveolae Homeostasis on Membrane Properties and Substrate Adhesion Characteristics of Adult Human Mesenchymal Stem Cells Stem Cell Research & Therapy. Apr, 2018 | Pubmed ID: 29615119 Mesenchymal Stem Cell-derived Extracellular Matrix Enhances Chondrogenic Phenotype of and Cartilage Formation by Encapsulated Chondrocytes in Vitro and in Vivo Acta Biomaterialia. Mar, 2018 | Pubmed ID: 29317369 One-Step Fabrication of Bone Morphogenetic Protein-2 Gene-Activated Porous Poly-L-Lactide Scaffold for Bone Induction Molecular Therapy. Methods & Clinical Development. Dec, 2017 | Pubmed ID: 29018836 Chondrogenesis of Human Bone Marrow Mesenchymal Stem Cells in 3-dimensional, Photocrosslinked Hydrogel Constructs: Effect of Cell Seeding Density and Material Stiffness Acta Biomaterialia. Aug, 2017 | Pubmed ID: 28611002 Tendon-Derived Extracellular Matrix Enhances Transforming Growth Factor-β3-Induced Tenogenic Differentiation of Human Adipose-Derived Stem Cells Tissue Engineering. Part A. Feb, 2017 | Pubmed ID: 27809678 Multilayered Polycaprolactone/gelatin Fiber-hydrogel Composite for Tendon Tissue Engineering Acta Biomaterialia. Apr, 2016 | Pubmed ID: 26945631 Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering Frontiers in Bioengineering and Biotechnology. 2015 | Pubmed ID: 26347860 In Vitro Repair of Meniscal Radial Tear Using Aligned Electrospun Nanofibrous Scaffold Tissue Engineering. Part A. Jul, 2015 | Pubmed ID: 25813386 Three-dimensional Osteogenic and Chondrogenic Systems to Model Osteochondral Physiology and Degenerative Joint Diseases Experimental Biology and Medicine (Maywood, N.J.). Sep, 2014 | Pubmed ID: 24994814 Stem Cell-based Microphysiological Osteochondral System to Model Tissue Response to Interleukin-1β Molecular Pharmaceutics. Jul, 2014 | Pubmed ID: 24830762 Cartilage Tissue Engineering Application of Injectable Gelatin Hydrogel with in Situ Visible-light-activated Gelation Capability in Both Air and Aqueous Solution Tissue Engineering. Part A. Sep, 2014 | Pubmed ID: 24575844 Enhancement of Tenogenic Differentiation of Human Adipose Stem Cells by Tendon-derived Extracellular Matrix Biomaterials. Dec, 2013 | Pubmed ID: 24044998 Application of Visible Light-based Projection Stereolithography for Live Cell-scaffold Fabrication with Designed Architecture Biomaterials. Jan, 2013 | Pubmed ID: 23092861 Influence of Decellularized Matrix Derived from Human Mesenchymal Stem Cells on Their Proliferation, Migration and Multi-lineage Differentiation Potential Biomaterials. Jun, 2012 | Pubmed ID: 22459197 Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs Meagan J. Makarcyzk1,2, Zhong Alan Li1,3, Ilhan Yu1, Haruyo Yagi1, Xiurui Zhang1, Lauren Yocum1, Eileen Li1, Madalyn R. Fritch1, Qi Gao4, Bruce A. Bunnell5, Stuart B. Goodman4,6, Rocky S. Tuan1,8, Peter G. Alexander1,7, Hang Lin1,2,7 1Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 2Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 3Department of Neurobiology, University of Pittsburgh School of Medicine, 4Department of Orthopaedic Surgery, Stanford University, 5Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, 6Department of Bioengineering, Stanford University, 7McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, 8The Chinese University of Hong Kong JoVE 64186 Bioengineering
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs Meagan J. Makarcyzk1,2, Zhong Alan Li1,3, Ilhan Yu1, Haruyo Yagi1, Xiurui Zhang1, Lauren Yocum1, Eileen Li1, Madalyn R. Fritch1, Qi Gao4, Bruce A. Bunnell5, Stuart B. Goodman4,6, Rocky S. Tuan1,8, Peter G. Alexander1,7, Hang Lin1,2,7 1Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 2Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 3Department of Neurobiology, University of Pittsburgh School of Medicine, 4Department of Orthopaedic Surgery, Stanford University, 5Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, 6Department of Bioengineering, Stanford University, 7McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, 8The Chinese University of Hong Kong JoVE 64186 Bioengineering