Harm Krugers Center for Neuroscience, Swammerdam Institute for Life Sciences University of Amsterdam Biography Publications Institution JoVE Articles Harm Krugers has not added a biography. If you are Harm Krugers and would like to personalize this page please email our Author Liaison for assistance. Publications Inhibiting 11β-hydroxysteroid Dehydrogenase Type 1 Prevents Stress Effects on Hippocampal Synaptic Plasticity and Impairs Contextual Fear Conditioning Neuropharmacology. Jun, 2014 | Pubmed ID: 24495397 Mineralocorticoid Receptors Guide Spatial and Stimulus-response Learning in Mice PloS One. 2014 | Pubmed ID: 24465979 Dendritic Morphology of Hippocampal and Amygdalar Neurons in Adolescent Mice is Resilient to Genetic Differences in Stress Reactivity PloS One. 2012 | Pubmed ID: 22701737 Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-making and C-fos Expression in Prefrontal Subregions of Rats PloS One. 2012 | Pubmed ID: 22693577 Interactions Between Noradrenaline and Corticosteroids in the Brain: from Electrical Activity to Cognitive Performance Frontiers in Cellular Neuroscience. 2012 | Pubmed ID: 22509154 Dysregulation of Rho GTPases in the αPix/Arhgef6 Mouse Model of X-linked Intellectual Disability is Paralleled by Impaired Structural and Synaptic Plasticity and Cognitive Deficits Human Molecular Genetics. Jan, 2012 | Pubmed ID: 21989057 Combined β-adrenergic and Corticosteroid Receptor Activation Regulates AMPA Receptor Function in Hippocampal Neurons Journal of Psychopharmacology (Oxford, England). Apr, 2012 | Pubmed ID: 21965192 Maternal Deprivation and Dendritic Complexity in the Basolateral Amygdala Neuropharmacology. Jan, 2012 | Pubmed ID: 21964522 Adult Hippocampal Glucocorticoid Receptor Expression and Dentate Synaptic Plasticity Correlate with Maternal Care Received by Individuals Early in Life Hippocampus. Feb, 2012 | Pubmed ID: 21240921 Blocking Mineralocorticoid Receptors Prior to Retrieval Reduces Contextual Fear Memory in Mice PloS One. 2011 | Pubmed ID: 22022574 Regulation of Excitatory Synapses and Fearful Memories by Stress Hormones Frontiers in Behavioral Neuroscience. 2011 | Pubmed ID: 22013419 Distinct Structural Plasticity in the Hippocampus and Amygdala of the Middle-aged Common Marmoset (Callithrix Jacchus) Experimental Neurology. Aug, 2011 | Pubmed ID: 21605555 Early Maternal Deprivation Affects Dentate Gyrus Structure and Emotional Learning in Adult Female Rats Psychopharmacology. Mar, 2011 | Pubmed ID: 20589492 Both Mineralocorticoid and Glucocorticoid Receptors Regulate Emotional Memory in Mice Neurobiology of Learning and Memory. Nov, 2010 | Pubmed ID: 20849967 Severe Early Life Stress Hampers Spatial Learning and Neurogenesis, but Improves Hippocampal Synaptic Plasticity and Emotional Learning Under High-stress Conditions in Adulthood The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2010 | Pubmed ID: 20463226 Fear Conditioning Enhances Spontaneous AMPA Receptor-mediated Synaptic Transmission in Mouse Hippocampal CA1 Area The European Journal of Neuroscience. Oct, 2009 | Pubmed ID: 19811531 Maternal Care Determines Rapid Effects of Stress Mediators on Synaptic Plasticity in Adult Rat Hippocampal Dentate Gyrus Neurobiology of Learning and Memory. Oct, 2009 | Pubmed ID: 19292996 Corticosterone Reduces Dendritic Complexity in Developing Hippocampal CA1 Neurons Hippocampus. Sep, 2009 | Pubmed ID: 19235231 Beta-adrenergic Facilitation of Synaptic Plasticity in the Rat Basolateral Amygdala in Vitro is Gradually Reversed by Corticosterone Learning & Memory (Cold Spring Harbor, N.Y.). Feb, 2009 | Pubmed ID: 19196909 Opposite Effects of Early Maternal Deprivation on Neurogenesis in Male Versus Female Rats PloS One. 2009 | Pubmed ID: 19180242 Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity Neuron. Jan, 2009 | Pubmed ID: 19146815 Maternal Care and Hippocampal Plasticity: Evidence for Experience-dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2008 | Pubmed ID: 18524909 Corticosteroid Hormones, Synaptic Strength and Emotional Memories: Corticosteroid Modulation of Memory -- a Cellular and Molecular Perspective Progress in Brain Research. 2008 | Pubmed ID: 18037023 Stress-induced Changes in Hippocampal Function Progress in Brain Research. 2008 | Pubmed ID: 18037003 Corticosterone Time-dependently Modulates Beta-adrenergic Effects on Long-term Potentiation in the Hippocampal Dentate Gyrus Learning & Memory (Cold Spring Harbor, N.Y.). May, 2007 | Pubmed ID: 17522027 LTP After Stress: Up or Down? Neural Plasticity. 2007 | Pubmed ID: 17502912 Tau-4R Suppresses Proliferation and Promotes Neuronal Differentiation in the Hippocampus of Tau Knockin/knockout Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2007 | Pubmed ID: 17341679 Stress, Corticosteroid Hormones and Hippocampal Synaptic Function CNS & Neurological Disorders Drug Targets. Oct, 2006 | Pubmed ID: 17073655 Improved Long-term Potentiation and Memory in Young Tau-P301L Transgenic Mice Before Onset of Hyperphosphorylation and Tauopathy The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2006 | Pubmed ID: 16571759 Timing is Essential for Rapid Effects of Corticosterone on Synaptic Potentiation in the Mouse Hippocampus Learning & Memory (Cold Spring Harbor, N.Y.). Mar-Apr, 2006 | Pubmed ID: 16547165 Learning Under Stress: How Does It Work? Trends in Cognitive Sciences. Apr, 2006 | Pubmed ID: 16513410 Corticosterone Shifts Different Forms of Synaptic Potentiation in Opposite Directions Hippocampus. 2005 | Pubmed ID: 15959917 Effects of Chronic Stress on Structure and Cell Function in Rat Hippocampus and Hypothalamus Stress (Amsterdam, Netherlands). Dec, 2004 | Pubmed ID: 16019587 Chronic Unpredictable Stress Impairs Long-term Potentiation in Rat Hippocampal CA1 Area and Dentate Gyrus in Vitro The European Journal of Neuroscience. May, 2003 | Pubmed ID: 12752792 Targeted Mutation of Cyln2 in the Williams Syndrome Critical Region Links CLIP-115 Haploinsufficiency to Neurodevelopmental Abnormalities in Mice Nature Genetics. Sep, 2002 | Pubmed ID: 12195424 Imaging Dendritic Spines of Rat Primary Hippocampal Neurons using Structured Illumination Microscopy Marijn Schouten*1, Giulia M. R. De Luca*2, Diana K. Alatriste González1, Babette E. de Jong2, Wendy Timmermans1, Hui Xiong1, Harm Krugers1, Erik M. M. Manders2, Carlos P. Fitzsimons1 1Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 2Van Leeuwenhoek Centre for Advanced Microscopy, Section Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam JoVE 51276 Neuroscience
Imaging Dendritic Spines of Rat Primary Hippocampal Neurons using Structured Illumination Microscopy Marijn Schouten*1, Giulia M. R. De Luca*2, Diana K. Alatriste González1, Babette E. de Jong2, Wendy Timmermans1, Hui Xiong1, Harm Krugers1, Erik M. M. Manders2, Carlos P. Fitzsimons1 1Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 2Van Leeuwenhoek Centre for Advanced Microscopy, Section Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam JoVE 51276 Neuroscience