Jonna Frasor Physiology and Biophysics, College of Medicine University of Illinois at Chicago Biography Publications Institution JoVE Articles Jonna Frasor has not added a biography. If you are Jonna Frasor and would like to personalize this page please email our Author Liaison for assistance. Publications Full Antagonism of the Estrogen Receptor Without a Prototypical Ligand Side Chain Nature Chemical Biology. Jan, 2017 | Pubmed ID: 27870835 Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of P65 Protein The Journal of Biological Chemistry. Feb, 2016 | Pubmed ID: 26683377 Correlative Analysis of MiRNA Expression and Oncotype Dx Recurrence Score in Estrogen Receptor Positive Breast Carcinomas PloS One. 2015 | Pubmed ID: 26717565 A Novel Aspirin Prodrug Inhibits NFκB Activity and Breast Cancer Stem Cell Properties BMC Cancer. Nov, 2015 | Pubmed ID: 26530254 NFκB Affects Estrogen Receptor Expression and Activity in Breast Cancer Through Multiple Mechanisms Molecular and Cellular Endocrinology. Dec, 2015 | Pubmed ID: 25450861 Growth Hormone Potentiates 17β-estradiol-dependent Breast Cancer Cell Proliferation Independently of IGF-I Receptor Signaling Endocrinology. Sep, 2013 | Pubmed ID: 23782942 14-3-3ζ As a Predictor of Early Time to Recurrence and Distant Metastasis in Hormone Receptor-positive and -negative Breast Cancers Breast Cancer Research and Treatment. Feb, 2013 | Pubmed ID: 23271328 Minireview: Inflammation: an Instigator of More Aggressive Estrogen Receptor (ER) Positive Breast Cancers Molecular Endocrinology (Baltimore, Md.). Mar, 2012 | Pubmed ID: 22301780 CBP Mediates NF-κB-dependent Histone Acetylation and Estrogen Receptor Recruitment to an Estrogen Response Element in the BIRC3 Promoter Molecular and Cellular Biology. Jan, 2012 | Pubmed ID: 22083956 An Integrated Bioinformatics Approach Identifies Elevated Cyclin E2 Expression and E2F Activity As Distinct Features of Tamoxifen Resistant Breast Tumors PloS One. 2011 | Pubmed ID: 21789246 The Stimulation of HSD17B7 Expression by Estradiol Provides a Powerful Feed-forward Mechanism for Estradiol Biosynthesis in Breast Cancer Cells Molecular Endocrinology (Baltimore, Md.). May, 2011 | Pubmed ID: 21372145 Estrogen Promotes Breast Cancer Cell Survival in an Inhibitor of Apoptosis (IAP)-dependent Manner Hormones & Cancer. Jun, 2010 | Pubmed ID: 21152357 Proinflammatory Cytokines Enhance Estrogen-dependent Expression of the Multidrug Transporter Gene ABCG2 Through Estrogen Receptor and NF{kappa}B Cooperativity at Adjacent Response Elements The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20705611 Estrogenic and Progestagenic Effects of Extracts of Justicia Pectoralis Jacq., an Herbal Medicine from Costa Rica Used for the Treatment of Menopause and PMS Maturitas. Jul, 2010 | Pubmed ID: 20452152 Positive Cross-talk Between Estrogen Receptor and NF-kappaB in Breast Cancer Cancer Research. Dec, 2009 | Pubmed ID: 19920189 Estrogenic Effects of Herbal Medicines from Costa Rica Used for the Management of Menopausal Symptoms Menopause (New York, N.Y.). Jul-Aug, 2009 | Pubmed ID: 19424091 Synergistic Up-regulation of Prostaglandin E Synthase Expression in Breast Cancer Cells by 17beta-estradiol and Proinflammatory Cytokines Endocrinology. Dec, 2008 | Pubmed ID: 18703630 Structure-activity Relationships for a Family of Benzothiophene Selective Estrogen Receptor Modulators Including Raloxifene and Arzoxifene ChemMedChem. Oct, 2007 | Pubmed ID: 17654759 Estrogen-regulated Gene Networks in Human Breast Cancer Cells: Involvement of E2F1 in the Regulation of Cell Proliferation Molecular Endocrinology (Baltimore, Md.). Sep, 2007 | Pubmed ID: 17550982 Gene Expression Preferentially Regulated by Tamoxifen in Breast Cancer Cells and Correlations with Clinical Outcome Cancer Research. Jul, 2006 | Pubmed ID: 16849584 Impact of Estrogen Receptor Beta on Gene Networks Regulated by Estrogen Receptor Alpha in Breast Cancer Cells Endocrinology. Oct, 2006 | Pubmed ID: 16809442 Estrogen Down-regulation of the Corepressor N-CoR: Mechanism and Implications for Estrogen Derepression of N-CoR-regulated Genes Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16141343 Distinctive Actions of Membrane-targeted Versus Nuclear Localized Estrogen Receptors in Breast Cancer Cells Molecular Endocrinology (Baltimore, Md.). Jun, 2005 | Pubmed ID: 15831524 Therapeutic Targeting in the Estrogen Receptor Hormonal Pathway Seminars in Oncology. Feb, 2004 | Pubmed ID: 15052541 Transcriptional Profiling of Estrogen-regulated Gene Expression Via Estrogen Receptor (ER) Alpha or ERbeta in Human Osteosarcoma Cells: Distinct and Common Target Genes for These Receptors Endocrinology. Jul, 2004 | Pubmed ID: 15033914 Selective Estrogen Receptor Modulators: Discrimination of Agonistic Versus Antagonistic Activities by Gene Expression Profiling in Breast Cancer Cells Cancer Research. Feb, 2004 | Pubmed ID: 14973112 Profiling of Estrogen Up- and Down-regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype Endocrinology. Oct, 2003 | Pubmed ID: 12959972 Response-specific and Ligand Dose-dependent Modulation of Estrogen Receptor (ER) Alpha Activity by ERbeta in the Uterus Endocrinology. Jul, 2003 | Pubmed ID: 12810572 Prolactin Regulation of Estrogen Receptor Expression Trends in Endocrinology and Metabolism: TEM. Apr, 2003 | Pubmed ID: 12670737 Regulation of Nuclear Receptor Transcriptional Activity by a Novel DEAD Box RNA Helicase (DP97) The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12466272 Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells Irida Kastrati1, Loruhama Delgado-Rivera2, Gergana Georgieva3, Gregory R. J. Thatcher2, Jonna Frasor1 1Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 2Medicinal Chemistry and Pharmacognosy, College of Medicine, University of Illinois at Chicago, 3College of Pharmacy, University of Illinois at Chicago JoVE 54798 Cancer Research
Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells Irida Kastrati1, Loruhama Delgado-Rivera2, Gergana Georgieva3, Gregory R. J. Thatcher2, Jonna Frasor1 1Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 2Medicinal Chemistry and Pharmacognosy, College of Medicine, University of Illinois at Chicago, 3College of Pharmacy, University of Illinois at Chicago JoVE 54798 Cancer Research