Leonard H. Augenlicht Department of Medicine Albert Einstein College of Medicine Biography Publications Institution JoVE Articles Leonard H. Augenlicht has not added a biography. If you are Leonard H. Augenlicht and would like to personalize this page please email our Author Liaison for assistance. Publications Vitamin D is a Determinant of Mouse Intestinal Lgr5 Stem Cell Functions Carcinogenesis. Oct, 2014 | Pubmed ID: 25344836 The Intestinal Epithelial Cell Differentiation Marker Intestinal Alkaline Phosphatase (ALPi) is Selectively Induced by Histone Deacetylase Inhibitors (HDACi) in Colon Cancer Cells in a Kruppel-like Factor 5 (KLF5)-dependent Manner The Journal of Biological Chemistry. Sep, 2014 | Pubmed ID: 25037223 Circulating Soluble Cytokine Receptors and Colorectal Cancer Risk Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jan, 2014 | Pubmed ID: 24192010 Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals Science (New York, N.Y.). Oct, 2013 | Pubmed ID: 24072822 The Effect of Lung Cancer on Cytokine Expression in Peripheral Blood Mononuclear Cells PloS One. 2013 | Pubmed ID: 23762239 Abdominal Obesity, Independent from Caloric Intake, Accounts for the Development of Intestinal Tumors in Apc(1638N/+) Female Mice Cancer Prevention Research (Philadelphia, Pa.). Mar, 2013 | Pubmed ID: 23466815 Dietary Cholecalciferol and Calcium Levels in a Western-style Defined Rodent Diet Alter Energy Metabolism and Inflammatory Responses in Mice The Journal of Nutrition. May, 2012 | Pubmed ID: 22437564 Intrinsic Mitochondrial Membrane Potential and Associated Tumor Phenotype Are Independent of MUC1 Over-expression PloS One. 2011 | Pubmed ID: 21966455 Intestinal Epithelial-specific PTEN Inactivation Results in Tumor Formation American Journal of Physiology. Gastrointestinal and Liver Physiology. Nov, 2011 | Pubmed ID: 21836055 Stable Differences in Intrinsic Mitochondrial Membrane Potential of Tumor Cell Subpopulations Reflect Phenotypic Heterogeneity International Journal of Cell Biology. 2011 | Pubmed ID: 21760799 Mybl2, Downregulated During Colon Epithelial Cell Maturation, is Suppressed by MiR-365 American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2011 | Pubmed ID: 21737779 Paneth Cell Marker Expression in Intestinal Villi and Colon Crypts Characterizes Dietary Induced Risk for Mouse Sporadic Intestinal Cancer Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21652773 MYBL2, a Link Between Proliferation and Differentiation in Maturing Colon Epithelial Cells Journal of Cellular Physiology. Mar, 2011 | Pubmed ID: 20857481 Transcriptional Attenuation in Colon Carcinoma Cells in Response to Butyrate Cancer Prevention Research (Philadelphia, Pa.). Oct, 2010 | Pubmed ID: 20841488 Prediction and Testing of Biological Networks Underlying Intestinal Cancer PloS One. 2010 | Pubmed ID: 20824133 Oxaliplatin Resistance Induced by ERCC1 Up-regulation is Abrogated by SiRNA-mediated Gene Silencing in Human Colorectal Cancer Cells Anticancer Research. Jul, 2010 | Pubmed ID: 20682979 Altered Dynamics of Intestinal Cell Maturation in Apc1638N/+ Mice Cancer Research. Jul, 2010 | Pubmed ID: 20570902 Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors is Mediated by an Sp1/Sp3-activated Transcriptional Program Involving Immediate-early Gene Induction Cancer Research. Jan, 2010 | Pubmed ID: 20068171 Gene Expression Profiling of Primary and Metastatic Colon Cancers Identifies a Reduced Proliferative Rate in Metastatic Tumors Clinical & Experimental Metastasis. 2010 | Pubmed ID: 19882219 An A13 Repeat Within the 3'-untranslated Region of Epidermal Growth Factor Receptor (EGFR) is Frequently Mutated in Microsatellite Instability Colon Cancers and is Associated with Increased EGFR Expression Cancer Research. Oct, 2009 | Pubmed ID: 19789347 PKCalpha Tumor Suppression in the Intestine is Associated with Transcriptional and Translational Inhibition of Cyclin D1 Experimental Cell Research. May, 2009 | Pubmed ID: 19232344 Butyrate and Vitamin D3 Induce Transcriptional Attenuation at the Cyclin D1 Locus in Colonic Carcinoma Cells Journal of Cellular Physiology. Mar, 2009 | Pubmed ID: 19034928 Western-style Diet-induced Colonic Tumors and Their Modulation by Calcium and Vitamin D in C57Bl/6 Mice: a Preclinical Model for Human Sporadic Colon Cancer Carcinogenesis. Jan, 2009 | Pubmed ID: 19017685 Proteomic Changes During Intestinal Cell Maturation in Vivo Journal of Proteomics. Dec, 2008 | Pubmed ID: 18824147 HDAC4 Promotes Growth of Colon Cancer Cells Via Repression of P21 Molecular Biology of the Cell. Oct, 2008 | Pubmed ID: 18632985 Intestinal Deletion of Pofut1 in the Mouse Inactivates Notch Signaling and Causes Enterocolitis Gastroenterology. Sep, 2008 | Pubmed ID: 18621050 Single-cell Transcription Site Activation Predicts Chemotherapy Response in Human Colorectal Tumors Cancer Research. Jul, 2008 | Pubmed ID: 18593893 Genetic Deficiency of Decorin Causes Intestinal Tumor Formation Through Disruption of Intestinal Cell Maturation Carcinogenesis. Jul, 2008 | Pubmed ID: 18550571 Expression of Selenium-binding Protein 1 Characterizes Intestinal Cell Maturation and Predicts Survival for Patients with Colorectal Cancer Molecular Nutrition & Food Research. Nov, 2008 | Pubmed ID: 18435490 PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab Cancer Research. Mar, 2008 | Pubmed ID: 18339877 Sulindac Suppresses Beta-catenin Expression in Human Cancer Cells European Journal of Pharmacology. Mar, 2008 | Pubmed ID: 18291362 P27kip1 Regulates Cdk2 Activity in the Proliferating Zone of the Mouse Intestinal Epithelium: Potential Role in Neoplasia Gastroenterology. Jul, 2007 | Pubmed ID: 17631145 C-Jun NH2-terminal Kinase 1 Plays a Critical Role in Intestinal Homeostasis and Tumor Suppression The American Journal of Pathology. Jul, 2007 | Pubmed ID: 17591974 Drug-induced Inactivation or Gene Silencing of Class I Histone Deacetylases Suppresses Ovarian Cancer Cell Growth: Implications for Therapy Cancer Biology & Therapy. May, 2007 | Pubmed ID: 17387270 JNK1 is Required for Sulindac-mediated Inhibition of Cell Proliferation and Induction of Apoptosis in Vitro and in Vivo European Journal of Pharmacology. Apr, 2007 | Pubmed ID: 17292881 Interaction of Genetic and Dietary Factors in Mouse Intestinal Tumorigenesis The Journal of Nutrition. Oct, 2006 | Pubmed ID: 16988154 Na(+)/monocarboxylate Transport (SMCT) Protein Expression Correlates with Survival in Colon Cancer: Molecular Characterization of SMCT Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16670197 Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and P21 Expression and Are Deregulated in Human Colon Cancer The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16533812 Growth Properties of Colonic Tumor Cells Are a Function of the Intrinsic Mitochondrial Membrane Potential Cancer Research. Feb, 2006 | Pubmed ID: 16452217 Kaiso-deficient Mice Show Resistance to Intestinal Cancer Molecular and Cellular Biology. Jan, 2006 | Pubmed ID: 16354691 Pathways in Nutritional Modulation of Homeostasis and Tumorigenesis The Journal of Nutrition. Dec, 2005 | Pubmed ID: 16317165 The Intrinsic Mitochondrial Membrane Potential of Colonic Carcinoma Cells is Linked to the Probability of Tumor Progression Cancer Research. Nov, 2005 | Pubmed ID: 16267009 P27kip1 in Intestinal Tumorigenesis and Chemoprevention in the Mouse Cancer Research. Oct, 2005 | Pubmed ID: 16230399 Gene Expression Profiling of Intestinal Epithelial Cell Maturation Along the Crypt-villus Axis Gastroenterology. Apr, 2005 | Pubmed ID: 15825089 Inactivation of P21WAF1/cip1 Enhances Intestinal Tumor Formation in Muc2-/- Mice The American Journal of Pathology. Apr, 2005 | Pubmed ID: 15793302 Methylation in the P21WAF1/cip1 Promoter of Apc+/-, P21+/- Mice and Lack of Response to Sulindac Oncogene. Mar, 2005 | Pubmed ID: 15688007 Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice Molecular and Cellular Biology. Sep, 2004 | Pubmed ID: 15314168 Customizing Chemotherapy for Colon Cancer: the Potential of Gene Expression Profiling Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. Jun, 2004 | Pubmed ID: 15296862 Tumor Necrosis Factor-alpha Related Gene Response to Epothilone B in Ovarian Cancer Gynecologic Oncology. Apr, 2004 | Pubmed ID: 15047209 Gene Expression Profiling-based Prediction of Response of Colon Carcinoma Cells to 5-fluorouracil and Camptothecin Cancer Research. Dec, 2003 | Pubmed ID: 14695196 Spontaneous Aberrant Crypt Foci in Apc1638N Mice with a Mutant Apc Allele The American Journal of Pathology. Nov, 2003 | Pubmed ID: 14578176 The Intrinsic Mitochondrial Membrane Potential (Deltapsim) is Associated with Steady-state Mitochondrial Activity and the Extent to Which Colonic Epithelial Cells Undergo Butyrate-mediated Growth Arrest and Apoptosis Cancer Research. Oct, 2003 | Pubmed ID: 14559818 TR3/Nur77 in Colon Cancer Cell Apoptosis Cancer Research. Sep, 2003 | Pubmed ID: 14500374 Targeted Inactivation of P27kip1 is Sufficient for Large and Small Intestinal Tumorigenesis in the Mouse, Which Can Be Augmented by a Western-style High-risk Diet Cancer Research. Aug, 2003 | Pubmed ID: 12941825 Gamma Delta T Cells Provide an Early Source of Interferon Gamma in Tumor Immunity The Journal of Experimental Medicine. Aug, 2003 | Pubmed ID: 12900519 Application of Gene Expression Profiling to Colon Cell Maturation, Transformation and Chemoprevention The Journal of Nutrition. Jul, 2003 | Pubmed ID: 12840217 Microarray Analysis in the Clinical Management of Cancer Hematology/oncology Clinics of North America. Apr, 2003 | Pubmed ID: 12737394 Environment-gene Interactions in Intestinal Cancer European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP). Aug, 2002 | Pubmed ID: 12570330 Short Chain Fatty Acids and Colon Cancer The Journal of Nutrition. Dec, 2002 | Pubmed ID: 12468628 Novel Detection and Differential Utilization of a C-myc Transcriptional Block in Colon Cancer Chemoprevention Cancer Research. Nov, 2002 | Pubmed ID: 12414619 A Gene Expression Profile That Defines Colon Cell Maturation in Vitro Cancer Research. Aug, 2002 | Pubmed ID: 12183439 Cell Type- and Promoter-dependent Modulation of the Wnt Signaling Pathway by Sodium Butyrate International Journal of Cancer. Journal International Du Cancer. Jan, 2002 | Pubmed ID: 11774242 Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures Tuba Bas1, Leonard H. Augenlicht1,2 1Department of Medicine, Albert Einstein College of Medicine, 2Department of Cell Biology, Albert Einstein College of Medicine JoVE 52026 Biology
Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures Tuba Bas1, Leonard H. Augenlicht1,2 1Department of Medicine, Albert Einstein College of Medicine, 2Department of Cell Biology, Albert Einstein College of Medicine JoVE 52026 Biology